Literature DB >> 7396108

Complement activation during cardiopulmonary bypass.

P L Haslam, P J Townsend, M A Branthwaite.   

Abstract

Conversion of C3, the third component of complement, has been studied using a two-dimensional immunoelectrophoretic method. Evidence of C3 conversion has been obtained in stored donor blood, in patients during and after cardiac surgery involving cardiopulmonary bypass, and occasionally during thoractomy for pulmonary resection. It is suggested that complement activation is one factor contributing to tissue injury after cardiopulmonary bypass.

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Year:  1980        PMID： 7396108     DOI： 10.1111/j.1365-2044.1980.tb03715.x

Source DB:  PubMed          Journal:  Anaesthesia        ISSN： 0003-2409            Impact factor:   6.955


  7 in total

1.  Complement activation during cardiac and thoracic vascular operations.

Authors:  P G Loubser
Journal:  Tex Heart Inst J       Date:  1987-12

2.  Rous-Whipple Award Lecture. Role of complement in lung inflammatory injury.

Authors:  P A Ward
Journal:  Am J Pathol       Date:  1996-10       Impact factor: 4.307

3.  Complement levels and C3 breakdown products in open-heart surgery: association of C3 conversion with the postpericardiotomy syndrome.

Authors:  S Meri; K Verkkala; A Miettinen; V Valtonen; E Linder
Journal:  Clin Exp Immunol       Date:  1985-06       Impact factor: 4.330

4.  Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation.

Authors:  C S Rinder; H M Rinder; B R Smith; J C Fitch; M J Smith; J B Tracey; L A Matis; S P Squinto; S A Rollins
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

5.  The effects of cardiopulmonary bypass on immune mechanisms of man.

Authors:  J P Lavelle; J P Duignan; M C Neligan
Journal:  Ir J Med Sci       Date:  1984-12       Impact factor: 1.568

6.  Requirement and role of C5a in acute lung inflammatory injury in rats.

Authors:  M S Mulligan; E Schmid; B Beck-Schimmer; G O Till; H P Friedl; R B Brauer; T E Hugli; M Miyasaka; R L Warner; K J Johnson; P A Ward
Journal:  J Clin Invest       Date:  1996-07-15       Impact factor: 14.808

7.  Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites.

Authors:  G O Till; K J Johnson; R Kunkel; P A Ward
Journal:  J Clin Invest       Date:  1982-05       Impact factor: 14.808
  7 in total

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