Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Linkage relationships and multipoint mapping of the human parotid salivary proteins (Pr, Pa, Db).

Literature DB >> 7395868

Linkage relationships and multipoint mapping of the human parotid salivary proteins (Pr, Pa, Db).

P L Yu, R C Karn, A D Merritt, E A Azen, P M Conneally.

Abstract

Based on data from 76 informative families, linkages between Pa and Pr and between Pr and Db have been established by two-point linkage analysis. In both pairs of loci, there were no significant sex heterogeneity in recombination fractions. Linkage between Pa and Db cannot be established based on two-point analyses, but a significant sex difference in the recombination fraction between Pa and Db was observed. Strong confirming evidence was obtained from three-point analysis to place Pa, Pr, and Db in one linkage group. The most likely order is Pa-Pr-Db, but the relative odds over second order Pr-Pa-Db are small. Haplotype frequencies of Pr, Pa, and Db were obtained based on the phenotypes of the 685 random Caucasians, providing evidence for marked linkage disequilibrium among the three loci.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1980 PMID： 7395868 PMCID： PMC1686124

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

13 in total

1. [Studies of genetic markers in human saliva. (I). Frequencies of Pa and Pb systems from parotid saliva of Japanese in Tokyo].

Authors: K Minaguchi; S Ikemoto; I Nakajima; K Suzuki
Journal: Bull Tokyo Dent Coll Date: 1976-11

2. [Studies of genetic markers in human saliva. (II). Frequencies of Pr and Db systems from parotid saliva of Japanese in Tokyo].

Authors: K Minaguchi; S Ikemoto; K Iida; K Suzuki
Journal: Bull Tokyo Dent Coll Date: 1976-11

3. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors: J Ott
Journal: Am J Hum Genet Date: 1974-09 Impact factor: 11.025

4. Genetic polymorphism of human salivary proline-rich proteins: further genetic analysis.

Authors: E A Azen; C L Denniston
Journal: Biochem Genet Date: 1974-08 Impact factor: 1.890

5. Genetic polymorphism of proline-rich human salivary proteins.

Authors: E A Azen; F G Oppenheim
Journal: Science Date: 1973-06-08 Impact factor: 47.728

6. Differential elution of histones from gel-trapped nuclei.

Authors: M Sung; O Smithies
Journal: Biopolymers Date: 1969 Impact factor: 2.505

7. Immunological relationships and a genetic interpretation of major and minor acidic proteins in human parotid saliva.

Authors: R D Friedman; R C Karn
Journal: Biochem Genet Date: 1977-06 Impact factor: 1.890

8. Linkage relationships of the proline-rich salivary proteins (Pr, Pa, Db).

Authors: P L Yu; R C Schwartz; A D Merritt; E A Azen; M L Rivas; R C Karn; M A Craft
Journal: Cytogenet Cell Genet Date: 1978

9. Genetic polymorphism of the major parotid salivary glycoprotein (Gl) with linkage to the genes for Pr, Db, and Pa.

Authors: E A Azen; C K Hurley; C Denniston
Journal: Biochem Genet Date: 1979-04 Impact factor: 1.890

10. Genetic studies of human acidic salivary protein (Pa).

Authors: R D Friedman; A D Merritt; M L Rivas
Journal: Am J Hum Genet Date: 1975-05 Impact factor: 11.025

11 in total

1. The human salivary protein complex (SPC): a large block of related genes.

Authors: P A Goodman; P L Yu; E A Azen; R C Karn
Journal: Am J Hum Genet Date: 1985-07 Impact factor: 11.025

2. Inheritance of the human salivary proline-rich proteins: a reinterpretation in terms of six loci forming two subfamilies.

Authors: N Maeda
Journal: Biochem Genet Date: 1985-06 Impact factor: 1.890

3. Description of a genetic polymorphism of a human proline-rich salivary protein, Pc, and its relationship to other proteins in the salivary protein complex (SPC).

Authors: R C Karn; P A Goodman; P L Yu
Journal: Biochem Genet Date: 1985-02 Impact factor: 1.890

4. Clones from the human gene complex coding for salivary proline-rich proteins.

Authors: E Azen; K M Lyons; T McGonigal; N L Barrett; L S Clements; N Maeda; E F Vanin; D M Carlson; O Smithies
Journal: Proc Natl Acad Sci U S A Date: 1984-09 Impact factor: 11.205

5. Genetic polymorphism of CON 1 and CON 2 salivary proteins detected by immunologic and concanavalin A reactions on nitrocellulose with linkage of CON 1 and CON 2 genes to the SPC (salivary protein gene complex).

Authors: E A Azen; P L Yu
Journal: Biochem Genet Date: 1984-02 Impact factor: 1.890

6. Genetic heterogeneity for fingertip arches.

Authors: T Reed; R S Young; P M Conneally
Journal: Am J Hum Genet Date: 1982-03 Impact factor: 11.025

7. Genetic polymorphism of PIF (parotid isoelectric focusing variant) proteins with linkage to the PPP (parotid proline-rich protein) gene complex.

Authors: E A Azen; C Denniston
Journal: Biochem Genet Date: 1981-06 Impact factor: 1.890

8. Human salivary proline-rich protein genes on chromosome 12.

Authors: E A Azen; P A Goodman; P A Lalley
Journal: Am J Hum Genet Date: 1985-03 Impact factor: 11.025

9. Polymorphism of Ps (parotid size variant) and detection of a protein (PmS) related to the Pm (parotid middle band) system with genetic linkage of Ps and Pm to Gl, Db, and Pr genetic determinants.

Authors: E A Azen; C Denniston
Journal: Biochem Genet Date: 1980-06 Impact factor: 1.890

10. Genetic polymorphisms of Pe and Po salivary proteins with probable linkage of their genes to the salivary protein gene complex (SPC).

Authors: E A Azen; P L Yu
Journal: Biochem Genet Date: 1984-12 Impact factor: 1.890