Literature DB >> 7395754

Distortion of cascade impactor measured size distribution due to bounce and blow-off.

N A Esmen, T C Lee.   

Abstract

Accurate measurement of particle size distribution by a cascade impactor requires that particles remain on the collection surfaces after impaction. Recent studies show that, when a solid aerosol is sampled, significant rebound and re-entrainment of particles occur in cascade impactors. A mathematical model of a cascade impactor including collection efficiency functions for solid aerosols on various impaction surfaces was developed and used to operate upon a series of log-normal size distributions. The impactor modeled was a six stage Andersen operated at 28.3 L/min. When bare metal or glass impaction surfaces are used, the impactor indicates non-log-normal distributions and the estimated distribution parameters are in error by as much as a factor of 7. When glass fiber impaction surfaces are used, although less serious errors are indicated, the deviation from log-normality is significant for aerosols with MMD larger than 3 micrometers. When oil covered impaction stages are used the indicated distributions parameters are acceptably close to the input parameters. The accuracy of the model was verified experimentally.

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Year:  1980        PMID: 7395754     DOI: 10.1080/15298668091424951

Source DB:  PubMed          Journal:  Am Ind Hyg Assoc J        ISSN: 0002-8894


  1 in total

1.  Effect of drug load and plate coating on the particle size distribution of a commercial albuterol metered dose inhaler (MDI) determined using the Andersen and Marple-Miller cascade impactors.

Authors:  M M Nasr; D L Ross; N C Miller
Journal:  Pharm Res       Date:  1997-10       Impact factor: 4.200

  1 in total

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