Blastomycoma of the cerebellum. An ultrastructural study.

Biopsy tissue from a cerebellar blastomycoma in a 48-year-old man was studied by electron microscopy. The fine structure of the fungi recapitulated that of the yeast forms described in cultures and culture implants. Mycelial forms were not encountered. The yeasts displayed lamellated cell walls and occasional multinucleation. Persistent broad-based budding with complex membranous profiles related to the cell membrane was prominent. The organisms were found within multinucleated giant cells and macrophages which exhibited subplasmalemmal linear densities and occasional desmosomal junctions.