Modifications in adrenal activity during hepatocarcinogenesis by N-2-fluorenylacetamide.

During chemical hepatocarcinogenesis by N-2-fluorenylacetamide, the hormonal status of female Sprague Dawley rats is largely modified. Adrenals present a modified activity which is evidenced by an enlargement of glomerulosa and reticularis zones and a decrease of the fasciculata, while medulla remain unchanged. The level of aldosterone remain quite normal in N-2-fluorenylacetamide treated rats despite changes observed in the glomerulosa. The cortisol level was lowered in agreement with the decreased size of the fasciculata. The estradiol level was normal despite the reduced activity of the ovaries. The possibility of a participation of the reticularis zone in the regulation of the estradiol level is suggested. The possible protective action of the adrenals during hepatocarcinogenesis is discussed.