| Literature DB >> 7394056 |
J Falconer, S Dekel, M J Francis.
Abstract
Prostaglandins A1, A2, B2, E2, and F2 alpha inhibit glycosaminoglycan sulphation in pig costal cartilage discs above 0.1 micrometer M (5-25 ug/ml); no effects were found at concentrations down to 25 pg/ml. At concentrations above 1 microgram/ml (0.02 mM) prostaglandin E2 and F2 alpha inhibited cartilage DNA synthesis. However at 100 ng/ml (10 microM) this inhibition was again observed. The basal production of prostaglandins E2 and F2 alpha by the cartilage discs after incubation was below 15 pg/ml. The exact concentrations at which these inhibitory effects were observed varied from experiment (i.e. animal) to experiment.Entities:
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Year: 1980 PMID： 7394056 DOI： 10.1016/0161-4630(80)90039-7
Source DB: PubMed Journal: Prostaglandins Med ISSN： 0161-4630