Literature DB >> 7393964

Anorexigenic effects of two amines obtained from Catha edulis Forsk. (Khat) in rats.

J L Zelger, E A Carlini.   

Abstract

The anorexigenic effects of cathine (phenylpropanolamine) and cathinone (alpha-aminopropiophenone), both amines obtained from Catha edulis Forsk. (Khat) were investigated by acute and chronic experiments in rats. Amphetamine was included for comparison purposes. Both khat amines reduced food intake when administered acutely and body weight when given chronically. Cathinone was more effective than cathine, and both were less active than amphetamine. Partial or total cross-tolerance was observed among the 3 drugs.

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Year:  1980        PMID： 7393964     DOI： 10.1016/0091-3057(80)90152-5

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  12 in total

Review 1.  Pharmacological approaches for the treatment of obesity.

Authors:  José-Antonio Fernández-López; Xavier Remesar; Màrius Foz; Marià Alemany
Journal:  Drugs       Date:  2002       Impact factor: 9.546

Review 2.  Khat use and appetite: an overview and comparison of amphetamine, khat and cathinone.

Authors:  Andrine M Lemieux; Bingshuo Li; Mustafa al'Absi
Journal:  J Ethnopharmacol       Date:  2014-11-28       Impact factor: 4.360

3.  The puzzle of drug-induced conditioned taste aversion: comparative studies with cathinone and amphetamine.

Authors:  A J Goudie; T Newton
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

Review 4.  Behavioural tolerance to amphetamine and other psychostimulants: the case for considering behavioural mechanisms.

Authors:  C Demellweek; A J Goudie
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

5.  Preference in rhesus monkeys given a choice between cocaine and d,l-cathinone.

Authors:  W L Woolverton; C E Johanson
Journal:  J Exp Anal Behav       Date:  1984-01       Impact factor: 2.468

6.  Acute and sub-chronic effects of purified cathinone from khat (Catha edulis) on behavioural profiles in vervet monkeys (Chlorocebus aethiops).

Authors:  Albert W Nyongesa; Jemimah A Oduma; Motohiro Nakajima; Hesbon O Odongo; Pius A Adoyo; Mustafa al'Absi
Journal:  Metab Brain Dis       Date:  2013-10-25       Impact factor: 3.584

7.  Cathinone, an alkaloid from khat leaves with an amphetamine-like releasing effect.

Authors:  P Kalix
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

8.  Rats become acutely tolerant to cathine after amphetamine or cathinone administration.

Authors:  M D Schechter
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

Review 9.  Phytochemicals in the Control of Human Appetite and Body Weight.

Authors:  Sonia A Tucci
Journal:  Pharmaceuticals (Basel)       Date:  2010-03-22

10.  Khat (Catha edulis Forsk.) Dependence Potential and Pattern of Use in Saudi Arabia.

Authors:  Siddig Ibrahim Abdelwahab; Rashad Mohammed Alsanosy; Bahaa-Eldin E A Rahim; Syam Mohan; Sara Taha; Manal Mohamed Elhassan; Maged El-Setouhy
Journal:  Biomed Res Int       Date:  2015-08-24       Impact factor: 3.411
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