Treatment of carcinoma in situ of the vulva with topical 5-fluorouracil.

Topical 5-fluorouracil (5-FU) has been suggested as a simple and effective approach to the treatment of carcinoma in situ of the vulva. In this study, 12 patients with carcinoma in situ of the vulva were evaluated and treated with topical 5-FU. Satisfactory results were obtained in 2. The nonresponders have subsequently undergone surgical therapy. Follow-up to date has been 9 to 96 months (average 38 months). The value of topical 5-FU in the treatment of carcinoma in situ of the vulva seems to be limited. Its use in vulvar neoplasia is discussed.