Literature DB >> 7392538

[Influence of propranolol and digoxin on the leftventricular pressure-volume-relation of the guinea pig (author's transl)].

A Hepp, K Kochsiek.   

Abstract

Leftventricular parameters of pressure, volume and contractility were recorded in the guinea pig treated with propranolol and digoxin. Propranolol shifts the isovolumetric pressure-volume-relation to higher enddiastolic volume. Pressure, rate of pressure rise, and heart rate considerably decrease. Cardiodepression of high-dose propranolol treatment is reversed in part by digoxin. Conclusions for application of beta-blockers, especially in imparied ventricular function, are discussed.

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Year:  1980        PMID： 7392538     DOI： 10.1007/bf01477170

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  8 in total

1.  Haemodynamic effects of beta-receptor blocking agents and digitalis in ischaemic coronary heart disease with angina pectoris.

Authors:  H Dunér; B Pernow
Journal:  Acta Med Scand       Date:  1973-12

2.  [Factors limiting increase of stroke volume by positive inotropism. Studies on sufficient hearts under continous postextrasystolic potentiation].

Authors:  G Kissling; R Jacob
Journal:  Pflugers Arch       Date:  1972       Impact factor: 3.657

3.  Left ventricular isovolumetric pressure-volume relations, "diastolic tone", and contractility in the rat heart after physical training.

Authors:  A Hepp; M Hansis; R Gülch; R Jacob
Journal:  Basic Res Cardiol       Date:  1974 Sep-Oct       Impact factor: 17.165

4.  Hemodynamic effect of a combined therapy with propranolol and digoxin.

Authors:  W Gebhardt; G Blümchen
Journal:  Cardiologia       Date:  1968

5.  [Improvement possibilities of myocardial contraction rate and stroke volume through inotropic mechanisms in the intact heart in situ].

Authors:  R Jacob; G Kissling; J Segarra-Domenech
Journal:  Arch Kreislaufforsch       Date:  1968-12

6.  Combined propranolol and digoxin therapy in angina pectoris.

Authors:  M H Crawford; M M LeWinter; R A O'Rourke; J S Karliner; J Ross
Journal:  Ann Intern Med       Date:  1975-10       Impact factor: 25.391

7.  Studies on digitalis. XVI. Effects on myocardial oxygen consumption.

Authors:  J W Covell; E Braunwald; J Ross; E H Sonnenblick
Journal:  J Clin Invest       Date:  1966-10       Impact factor: 14.808

8.  [Influence of digitalis on pindolol activity in exercise-induced cardiac failure in patients with coronary disease (author's transl)].

Authors:  M Oeff; O A Beck; H Hochrein
Journal:  Dtsch Med Wochenschr       Date:  1979-01-19       Impact factor: 0.628
  8 in total

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