Literature DB >> 7392035

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.

V A Levin.   

Abstract

The rat brain capillary permeability coefficient was determined for 27 compounds. The relationship of permeability to octanol/water partition coefficient and molecular weight was found to be predictable for drugs with molecular weights less than 400.

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Year:  1980        PMID： 7392035     DOI： 10.1021/jm00180a022

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  155 in total

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2.  Permeation studies in vitro and in vivo of potential radiopharmaceuticals with affinity to neuro receptors.

Authors:  M Friebe; K Suda; H Spies; R Syhre; R Berger; B Johannsen; E Chiotellis; S D Krämer; H Wunderli-Allenspach
Journal:  Pharm Res       Date:  2000-06       Impact factor: 4.200

3.  Computation of log BB values for compounds transported through carrier-mediated mechanisms using in vitro permeability data from brain microvessel endothelial cell (BMEC) monolayers.

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Review 5.  Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

Authors:  Elizabeth C M de Lange; Meindert Danhof
Journal:  Clin Pharmacokinet       Date:  2002       Impact factor: 6.447

6.  Computational models to predict blood-brain barrier permeation and CNS activity.

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Review 7.  Improving the prediction of the brain disposition for orally administered drugs using BDDCS.

Authors:  Fabio Broccatelli; Caroline A Larregieu; Gabriele Cruciani; Tudor I Oprea; Leslie Z Benet
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8.  Permeability of the blood-brain barrier to a rhenacarborane.

Authors:  Patrick M Hawkins; Paul A Jelliss; Naoko Nonaka; Xiaoming Shi; William A Banks
Journal:  J Pharmacol Exp Ther       Date:  2009-01-29       Impact factor: 4.030

9.  Salvage chemotherapy with procarbazine and fotemustine combination in the treatment of temozolomide treated recurrent glioblastoma patients.

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10.  QSAR studies of copper azamacrocycles and thiosemicarbazones: MM3 parameter development and prediction of biological properties.

Authors:  Peter Wolohan; Jeongsoo Yoo; Michael J Welch; David E Reichert
Journal:  J Med Chem       Date:  2005-08-25       Impact factor: 7.446
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