Literature DB >> 73904

Immunological mechanism for spontaneous abortion in systemic lupus erythematosus.

B Breshnihan, R R Grigor, M Oliver, R M Lewkonia, G R Hughes, R E Lovins, W P Faulk.   

Abstract

The incidence of lymphocytotoxic antibodies in patients with systemic lupus erythematosus (S.L.E.) was significantly lower during pregnancies ending in normal live births than in pregnancies ending in spontaneous abortions (P less than 0.005). It was possible to absorb the lymphocytotoxic antibodies from S.L.E. sera with purified trophoblast antigens. The presence of a trophoblast-reactive lymphocytotoxic antibody which fails to disappear during pregnancies which end in abortion suggests an immunological mechanism for spontaneous abortion in S.L.E.

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Year:  1977        PMID： 73904     DOI： 10.1016/s0140-6736(77)90441-x

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  8 in total

Review 1.  Multiple autoantibodies associated with autoimmune reproductive failure.

Authors:  Yaniv Sherer; Shelly Tartakover-Matalon; Miri Blank; Eiji Matsuura; Yehuda Shoenfeldlt
Journal:  J Assist Reprod Genet       Date:  2003-02       Impact factor: 3.412

2.  Antigens of human trophoblasts: a working hypothesis for their role in normal and abnormal pregnancies.

Authors:  W P Faulk; A Temple; R E Lovins; N Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

3.  Lymphocytotoxic antibodies in systemic lupus erythematosus: their clinical significance.

Authors:  B Bresnihan; R R Grigor; G R Hughes
Journal:  J Clin Pathol Suppl (R Coll Pathol)       Date:  1979

Review 4.  Systemic lupus erythematosus--an autoimmune disease?

Authors:  E J Holborow
Journal:  J Clin Pathol Suppl (R Coll Pathol)       Date:  1978

5.  Congenital heart block and maternal systemic lupus erythematosus.

Authors:  E Esscher; J S Scott
Journal:  Br Med J       Date:  1979-05-12

6.  Prevalence of antinuclear antibodies in patients with habitual abortion and in normal and toxemic pregnancies.

Authors:  I Garcia-De La Torre; L Hernandez-Vazquez; J Angulo-Vazquez; A Romero-Ornelas
Journal:  Rheumatol Int       Date:  1984       Impact factor: 2.631

7.  The testosterone hypothesis: Assessment since Geschwind and Behan, 1982.

Authors:  A M Galaburda
Journal:  Ann Dyslexia       Date:  1990-01

8.  Obstetric and gynaecological profile in patients with primary Sjögren's syndrome.

Authors:  F N Skopouli; S Papanikolaou; V Malamou-Mitsi; N Papanikolaou; H M Moutsopoulos
Journal:  Ann Rheum Dis       Date:  1994-09       Impact factor: 19.103
  8 in total

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