| Literature DB >> 7390164 |
Abstract
The chronic treatment of female C3H/Sn mice with phenformin (2 mg/day) and diphenylhydantoin (2 mg/day) prolonged mean life span by 23 and 25%, respectively, and decreased spontaneous tumour incidence by 4.0 and 2.3 times, respectively. The chronic treatment of mice with L-dopa (2 mg/day) did not change these parameters and decreased the multiplicity of mammary tumours. The mechanisms of the drug action on mouse life span and tumour incidence are discussed.Entities:
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Year: 1980 PMID： 7390164 DOI： 10.1159/000212423
Source DB: PubMed Journal: Gerontology ISSN： 0304-324X Impact factor: 5.140