Literature DB >> 7389750

4-Hydroxy-5-oxo-4,5-dihydrobenzo(a)pyrene, a new metabolite of benzo(a)pyrene.

G Lhoëst.   

Abstract

The detection and the isolation in phenobarbital-induced rat liver microsomal incubation systems of a new metabolite of benzo(a)pyrene are described. The structure of this metabolite and the way in which it is formed are described.

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Year:  1980        PMID： 7389750     DOI： 10.1007/BF03189442

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  6 in total

Review 1.  Chemical carcinogenesis.

Authors:  C Heidelberger
Journal:  Annu Rev Biochem       Date:  1975       Impact factor: 23.643

2.  "K-region" oxides and related oxidized metabolites of carcinogenic aromatic hydrocarbons.

Authors:  R G Harvey; S H Goh; C Cortez
Journal:  J Am Chem Soc       Date:  1975-06-11       Impact factor: 15.419

3.  The metabolism of methylated aminoazo dyes. IV. Dietary factors enhancing demethylation in vitro.

Authors:  R R BROWN; J A MILLER; E C MILLER
Journal:  J Biol Chem       Date:  1954-07       Impact factor: 5.157

Review 4.  Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis.

Authors:  P Sims; P L Grover
Journal:  Adv Cancer Res       Date:  1974       Impact factor: 6.242

Review 5.  Benzo[a]pyrene carcinogenesis: a biochemical selection mechanism.

Authors:  J K Selkirk
Journal:  J Toxicol Environ Health       Date:  1977-07

6.  Analytical study of microsomes and isolated subcellular membranes from rat liver. II. Preparation and composition of the microsomal fraction.

Authors:  A Amar-Costesec; H Beaufay; M Wibo; D Thinès-Sempoux; E Feytmans; M Robbi; J Berthet
Journal:  J Cell Biol       Date:  1974-04       Impact factor: 10.539
  6 in total
  1 in total

1.  Isolation and mass spectrometric identification of gitoxin metabolites excreted in bile.

Authors:  L N Kadima; G Lhoest; M Lesne
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1982       Impact factor: 2.441
  1 in total

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