| Literature DB >> 7389260 |
C Hignite, J Uetrecht, C Tschanz, D Azarnoff.
Abstract
A method is reported for simultaneous measurement of the kinetics of R and S warfarin enantiomers. Pure pentadeuterated R and S enantiomers were each combined with unlabeled enatiomers to form "pseudo"-racemic mixtures which were given (0.75 mg/kg) to 5 healthy subjects. Plasma R and S enantiomer levels were measured by gas chromatography--mass spectrometry. Elimination half-lifes (t1/2S) and volumes of distribution (VdS) of the enantiomers were not altered by the presence of the other.Entities:
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Year: 1980 PMID： 7389260 DOI： 10.1038/clpt.1980.137
Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875