Literature DB >> 7389192

Immunopotentiation by pyrimethamine in the mouse.

Y H Thong, A Ferrante.   

Abstract

Pyrimethamine, a 2,4-diaminopyrimidine useful in the treatment of malaria and toxoplasmosis, was found to enhance antibody and delayed-type hypersensitivity responses to sheep red cells in mice. The immunodepression of tumour-bearing mice was also reversed by pyrimethamine. This drug may prove useful as a general immunostimulant in clinical situations where the immune system has been compromised by cancer or other debilitating illnesses.

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Year:  1980        PMID： 7389192      PMCID： PMC1537946     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  8 in total

1.  2:4-diaminopyrimidines- a new series of antimalarials.

Authors:  E A FALCO; L G GOODWIN; G H HITCHINGS; I M ROLLO; P B RUSSELL
Journal:  Br J Pharmacol Chemother       Date:  1951-06

2.  Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity.

Authors:  E R Giblett; J E Anderson; F Cohen; B Pollara; H J Meuwissen
Journal:  Lancet       Date:  1972-11-18       Impact factor: 79.321

3.  The chemotherapy of rodent malaria, XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity.

Authors:  W Peters
Journal:  Ann Trop Med Parasitol       Date:  1975-06

4.  Primaquine inhibits mitogen-induced human lymphocyte proliferative responses.

Authors:  Y H Thong; A Ferrante; B Rowan-Kelly
Journal:  Trans R Soc Trop Med Hyg       Date:  1978       Impact factor: 2.184

5.  Inhibition of mitogen-induced human lymphocyte proliferative responses by tetracycline analogues.

Authors:  Y H Thong; A Ferrante
Journal:  Clin Exp Immunol       Date:  1979-03       Impact factor: 4.330

6.  Miconazole prolongs murine skin graft survival.

Authors:  Y H Thong; A Ferrante
Journal:  Clin Exp Immunol       Date:  1979-01       Impact factor: 4.330

7.  Suppression of immunological responses in mice by treatment with amphotericin B.

Authors:  A Ferrante; B Rowan-Kelly; Y H Thong
Journal:  Clin Exp Immunol       Date:  1979-10       Impact factor: 4.330

8.  Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity.

Authors:  E R Giblett; A J Ammann; D W Wara; R Sandman; L K Diamond
Journal:  Lancet       Date:  1975-05-03       Impact factor: 79.321
  8 in total
  2 in total

1.  Reversal of suppressed cell-mediated immune reaction by pyrimethamine.

Authors:  J X Zhang; X Z Zhao
Journal:  Acta Acad Med Wuhan       Date:  1985

2.  Antimalarial activity of cyclosporin A.

Authors:  K Thommen-Scott
Journal:  Agents Actions       Date:  1981-12
  2 in total

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