Literature DB >> 7387856

Serum sialic acid and CEA concentrations in human breast cancer.

A Hogan-Ryan, J J Fennelly, M Jones, B Cantwell, M J Duffy.   

Abstract

The concentration of bound sialic acid in the sera of 56 normal subjects and 65 subjects with breast cancer was measured, in order to determine (1) whether serum sialic acid concentrations are raised in breast cancer and (2) whether the concentration of sialic acid in serum reflects tumour stage. The amount of sialic acid in serum was compared to serum carcinoembryonic antigen (CEA) values. Urinary hydroxyproline and serum alkaline phosphatase concentrations were used as indicators of bone and liver involvement. Erythrocyte sedimentation rate (ESR) was also measured. Significantly elevated serum sialic acid concentrations were found in breast cancer, and showed correlation with tumour stage. Serum sialic acid values did not correlate with CEA values. The results suggest that measurement of serum sialic acid concentrations may be of adjunctive value in assessing tumour stage.

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Year:  1980        PMID： 7387856      PMCID： PMC2010272          DOI： 10.1038/bjc.1980.101

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  15 in total

1.  Biological markers in breast carcinoma. II. Clinical correlations with human chorionic gonadotrophin.

Authors:  D C Tormey; T P Waalkes; R M Simon
Journal:  Cancer       Date:  1977-06       Impact factor: 6.860

2.  A biochemical approach to the staging of human breast cancer.

Authors:  R C Coombes; T J Powles; J C Gazet; H T Ford; A G Nash; J P Sloane; C J Hillyard; P Thomas; J W Keyser; D Marcus; N Zinberg; W H Stimson; A M Neville
Journal:  Cancer       Date:  1977-08       Impact factor: 6.860

3.  Surface glycoproteins of normal and transformed cells: a difference determined by sialic acid and a growth-dependent sialyl transferase.

Authors:  L Warren; J P Fuhrer; C A Buck
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

4.  Cell surface modification in the treatment of experimental cancer: neuraminidase or concanavalin A.

Authors:  R L Simmons; A Rios
Journal:  Cancer       Date:  1974-10       Impact factor: 6.860

5.  Sialic acid on leukemia cells: relation to morphology and tumor immunity.

Authors:  R C Reed; J U Gutterman; G M Mavlight; E M Hersh
Journal:  Proc Soc Exp Biol Med       Date:  1974-03

6.  Immunospecific regression of methylcholanthrene fibrosarcoma with the use of neuraminidase.

Authors:  R L Simmons; A Rios; G Lundgren; P K Ray; C F McKhann; G R Haywood
Journal:  Surgery       Date:  1971-07       Impact factor: 3.982

7.  Early morning hydroxyproline excretion in patients with breast cancer.

Authors:  T J Powles; G Rosset; C L Leese; P K Bondy
Journal:  Cancer       Date:  1976-12       Impact factor: 6.860

8.  Protein-bound carbohydrates in breast cancer. Liquid-chromatographic analysis for mannose, galactose, fucose, and sialic acid in serum.

Authors:  J E Mrochek; S R Dinsmore; D C Tormey; T P Waalkes
Journal:  Clin Chem       Date:  1976-09       Impact factor: 8.327

9.  Neuraminidase-mediated augmentation of in vitro immune response of patients with solid tumors.

Authors:  E Watkins; B N Gray; L L Anderson; O L Baralt; L R Nebril; M F Waters; C K Connery
Journal:  Int J Cancer       Date:  1974-12-15       Impact factor: 7.396

10.  Sialoproteinaemia: lack of correlation with inhibition of in vitro lymphoblastosis induced by phytohaemagglutinin or alloantigen.

Authors:  B N Gray; R R Kopito; L L Anderson; O L Baralt; C K Connery; E Watkins
Journal:  Clin Exp Immunol       Date:  1976-08       Impact factor: 4.330
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  13 in total

1.  Elevated serum sialic acid in pregnancy.

Authors:  M Crook; S Constable; P Lumb; J Rymer
Journal:  J Clin Pathol       Date:  1997-06       Impact factor: 3.411

2.  Circulating Tumor Cells in Metastatic Breast Cancer: A Prognostic and Predictive Marker.

Authors:  Sayyed Farshid Moussavi-Harami; Kari B Wisinski; David J Beebe
Journal:  J Patient Cent Res Rev       Date:  2014

Review 3.  Serum sialylation changes in cancer.

Authors:  Zejian Zhang; Manfred Wuhrer; Stephanie Holst
Journal:  Glycoconj J       Date:  2018-04-21       Impact factor: 2.916

4.  Evaluation of follow-up methods to detect relapse after mastectomy in breast cancer patients.

Authors:  B Cantwell; J J Fennelly; M Jones
Journal:  Ir J Med Sci       Date:  1982-01       Impact factor: 1.568

5.  Glycosylated haemoglobin levels in breast cancer patients receiving cytotoxic chemotherapy.

Authors:  B Cantwell; I F Shirley; J J Fennelly
Journal:  Breast Cancer Res Treat       Date:  1981       Impact factor: 4.872

6.  Axillary versus peripheral blood levels of sialic acid, ferritin, and CEA in patients with breast cancer.

Authors:  M Monti; S Catania; E Locatelli; R Gandini; A Reggiani; E Cunietti
Journal:  Breast Cancer Res Treat       Date:  1990-12       Impact factor: 4.872

7.  A suggested guiding panel of seromarkers for efficient discrimination between primary and secondary human hepatocarcinoma.

Authors:  Nabil Mohie Abdel-Hamid; M M Abouzied; M H Nazmy; M A Fawzy; A S Gerges
Journal:  Tumour Biol       Date:  2015-09-19

8.  An improved method for the measurement of total lipid-bound sialic acids after cleavage of alpha 2,8 sialic acid linkage with Vibrio cholerae sialidase in the presence of cholic acid, SDS and Ca2+.

Authors:  M A Maliakal; M H Ravindranath; R F Irie; D L Morton
Journal:  Glycoconj J       Date:  1994-04       Impact factor: 2.916

9.  Plasma lipid-bound sialic acid alterations in neoplastic diseases.

Authors:  C Dwivedi; M Dixit; R E Hardy
Journal:  Experientia       Date:  1990-01-15

10.  Serum sialic acid in malignant tumors, bacterial infections, and chronic liver diseases.

Authors:  N Stefenelli; H Klotz; A Engel; P Bauer
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553
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