| Literature DB >> 7387351 |
K H Krause, H Schmidt-Gayk, D Gutscher, G Gutscher.
Abstract
No significant difference was found in a comparison between the values of unreduced serum folic acid of 48 epileptics treated with hydantoin and 38 controls as measured by a competitive protein-binding assay. The average folic acid value was 7.73 nmol/l in the epileptics, a little higher than the 7.18 nmol/l found in the controls. This result supports the hypothesis that the folate deficiency in epileptics is caused by blocking the conversion of folic acid to 5-methyltetrahydrofolic acid by phenytoin.Entities:
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Year: 1980 PMID： 7387351 DOI： 10.1007/bf00365747
Source DB: PubMed Journal: Arch Psychiatr Nervenkr (1970)