Literature DB >> 7385057

Teratogenic effects of combined administration of ethylenethiourea and nitrite in mice.

S Teramoto, R Saito, Y Shirasu.   

Abstract

Teratogenic potential of ethylenethiourea (ETU) was investigated in SLC-ICR mice after its reaction with sodium nitrite. ETU was given orally in doses of 400 mg/kg on various days of pregnancy in combination with 200 mg/kg NaNO2 at varied intervals. When NaNO2 was given to females immediately after their treatment with ETU on day 6 or 8 of pregnancy, fetal survival was significantly decreased. Various types of malformations were observed in the living fetuses from mothers treated on day 6, 8, or 10 of pregnancy, but not on day 12. The teratogenicity disappeared when NaNO2 was given 2 h after the treatment with ETU.

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Year:  1980        PMID： 7385057     DOI： 10.1002/tera.1420210109

Source DB:  PubMed          Journal:  Teratology        ISSN： 0040-3709


  7 in total

1.  Nitrosatable drug exposure during early pregnancy and neural tube defects in offspring: National Birth Defects Prevention Study.

Authors:  Jean D Brender; Martha M Werler; Katherine E Kelley; Ann M Vuong; Mayura U Shinde; Qi Zheng; John C Huber; Joseph R Sharkey; John S Griesenbeck; Paul A Romitti; Peter H Langlois; Lucina Suarez; Mark A Canfield
Journal:  Am J Epidemiol       Date:  2011-11-01       Impact factor: 4.897

2.  Assessing bottled water nitrate concentrations to evaluate total drinking water nitrate exposure and risk of birth defects.

Authors:  Peter J Weyer; Jean D Brender; Paul A Romitti; Jiji R Kantamneni; David Crawford; Joseph R Sharkey; Mayura Shinde; Scott A Horel; Ann M Vuong; Peter H Langlois
Journal:  J Water Health       Date:  2014-12       Impact factor: 1.744

3.  Transplacental induction of myeloschisis associated with hindbrain crowding and other malformations in the central nervous system in Long-Evans rats.

Authors:  K Sato; N Nakagata; C F Hung; M Wada; T Shimoji; S Ishii
Journal:  Childs Nerv Syst       Date:  1985       Impact factor: 1.475

4.  Nitrosatable drug exposure during the first trimester of pregnancy and selected congenital malformations.

Authors:  Jean D Brender; Martha M Werler; Mayura U Shinde; Ann M Vuong; Katherine E Kelley; John C Huber; Joseph R Sharkey; John S Griesenbeck; Paul A Romitti; Sadia Malik; Lucina Suarez; Peter H Langlois; Mark A Canfield
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2012-08-18

5.  (7-Chloro-2-oxo-2H-chromen-4-yl)methyl di-ethyl-carbamodi-thio-ate.

Authors:  T G Meenakshi; J Shylajakumari; H C Devarajegowda; K Mahesh Kumar; O Kotresh
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-08-14

6.  Maternal dietary intake of nitrates, nitrites and nitrosamines and selected birth defects in offspring: a case-control study.

Authors:  John C Huber; Jean D Brender; Qi Zheng; Joseph R Sharkey; Ann M Vuong; Mayura U Shinde; John S Griesenbeck; Lucina Suarez; Peter H Langlois; Mark A Canfield; Paul A Romitti; Peter J Weyer
Journal:  Nutr J       Date:  2013-03-21       Impact factor: 3.271

7.  Prenatal nitrate intake from drinking water and selected birth defects in offspring of participants in the national birth defects prevention study.

Authors:  Jean D Brender; Peter J Weyer; Paul A Romitti; Binayak P Mohanty; Mayura U Shinde; Ann M Vuong; Joseph R Sharkey; Dipankar Dwivedi; Scott A Horel; Jiji Kantamneni; John C Huber; Qi Zheng; Martha M Werler; Katherine E Kelley; John S Griesenbeck; F Benjamin Zhan; Peter H Langlois; Lucina Suarez; Mark A Canfield
Journal:  Environ Health Perspect       Date:  2013-06-14       Impact factor: 9.031
  7 in total

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