Literature DB >> 7384816

The testicular feminized rat: a naturally occurring model of androgen independent brain masculinization.

B H Shapiro, D C Levine, N T Adler.   

Abstract

Although genotypically male (XY), the testicular feminized rat develops as an anatomic female because of an inherited deficiency in intracellular androgen receptors that prevents androgen imprinting of sexual primordia. However, the ability of testicular feminized rats to exhibit male-like sexual behavior and little feminine sexual behavior suggests that the brain can be masculinized without androgens.

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Year:  1980        PMID: 7384816     DOI: 10.1126/science.7384816

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  8 in total

1.  Growth hormone: a newly identified developmental organizer.

Authors:  Rajat K Das; Sarmistha Banerjee; Bernard H Shapiro
Journal:  J Endocrinol       Date:  2016-12-15       Impact factor: 4.286

2.  Systemic hypotensive effects of testosterone are androgen structure-specific and neuronal nitric oxide synthase-dependent.

Authors:  Mercedes Perusquía; Clayton D Greenway; Lisa M Perkins; John N Stallone
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2015-05-06       Impact factor: 3.619

3.  Feminization imprinted by developmental growth hormone.

Authors:  Sarmistha Banerjee; Rajat K Das; Bernard H Shapiro
Journal:  Mol Cell Endocrinol       Date:  2018-08-29       Impact factor: 4.102

Review 4.  A role for the androgen receptor in the sexual differentiation of the olfactory system in mice.

Authors:  Cristian Bodo
Journal:  Brain Res Rev       Date:  2007-09-05

5.  Irreversible perinatal imprinting of adult expression of the principal sex-dependent drug-metabolizing enzyme CYP2C11.

Authors:  Rajat Kumar Das; Sarmistha Banerjee; Bernard H Shapiro
Journal:  FASEB J       Date:  2014-06-18       Impact factor: 5.191

6.  Development of male gender identity/role and a sexual orientation towards women in a 46,XY subject with an incomplete form of the androgen insensitivity syndrome.

Authors:  L Gooren; P T Cohen-Kettenis
Journal:  Arch Sex Behav       Date:  1991-10

7.  Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens.

Authors:  Andrea E Hanson; Mercedes Perusquia; John N Stallone
Journal:  Biol Sex Differ       Date:  2020-08-26       Impact factor: 5.027

8.  Early expression of requisite developmental growth hormone imprinted cytochromes P450 and dependent transcription factors.

Authors:  Sarmistha Banerjee; Allison M Hayes; Bernard H Shapiro
Journal:  Endocr Connect       Date:  2021-09-20       Impact factor: 3.335

  8 in total

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