Literature DB >> 7384549

Vasoactive intestinal polypeptide (VIP) inhibits prostaglandin-F2 alpha-induced activity of the rabbit myometrium.

B Ottesen, G Wagner, J Fahrenkrug.   

Abstract

Seven female rabbits ahd myometrial autografts transplanted into ear-chambers. The electrical activity of the graft was recorded and mechanical activity observed. Vasoactive intestinal polypeptide (VIP) dose-dependently inhibited myometrial activity induced by prostaglandin-F2 alpha. This evidence and the occurrence of "VIPergic" nerve fibres, which seem to innervate the myometrial cells, suggest that VIP may play a physiological role in the local control of the myometrial activity.

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Year:  1980        PMID: 7384549     DOI: 10.1016/0090-6980(80)90076-3

Source DB:  PubMed          Journal:  Prostaglandins        ISSN: 0090-6980


  3 in total

1.  Peptide-immunoreactive nerves in the mammalian female genital tract.

Authors:  W M Huang; J Gu; M A Blank; J M Allen; S R Bloom; J M Polak
Journal:  Histochem J       Date:  1984-12

2.  Nervous release of vasoactive intestinal polypeptide from the feline uterus: pharmacological characteristics.

Authors:  J Fahrenkrug; B Ottesen
Journal:  J Physiol       Date:  1982-10       Impact factor: 5.182

3.  Mechanism of action of vasoactive intestinal polypeptide on myometrial smooth muscle of rabbit and guinea-pig.

Authors:  T B Bolton; R J Lang; B Ottesen
Journal:  J Physiol       Date:  1981-09       Impact factor: 5.182

  3 in total

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