Literature DB >> 738410

Stereoselectivity of oxotremorine antagonists containing a chiral pyrrolidine group.

B Ringdahl, R Dahlbom.   

Abstract

Oxotremorine (Ia) and its succinimide analogue (IIa) have been substituted in the pyrrolidine ring with a methyl group in the 2- or 3-positions. The compounds are oxotremorine antagonists. The 2-methyl-substituted enantiomers show stereoselectivity, the S-isomers being the most active.

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Year:  1978        PMID： 738410     DOI： 10.1007/bf01981455

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  Acetylene compounds of potential pharmacological value. XIX. N-(dialkylaminoalkynyl)-substituted succinimides and 2-pyrrolidones as partial cholinergic agonists.

Authors:  U Svensson; R Dahlbom
Journal:  Acta Pharm Suec       Date:  1975

2.  Absolute configuration and parasympathetic action: pharmacodynamics of enantiomorphic and diastereoisomeric esters of beta-methylcholine.

Authors:  B W Ellenbroek; R J Nivard; J M van Rossum; E J Ariëns
Journal:  J Pharm Pharmacol       Date:  1965-07       Impact factor: 3.765

3.  Stereospecificity of oxotremorine antagonists.

Authors:  R Dahlbom; A Lindquist; S Lindgren; U Svensson; B Ringdahl; M R Blair
Journal:  Experientia       Date:  1974-10-15

4.  Acetylene compounds of potential pharmacological value. XIV. N-(t-aminoalkynyl)-substituted succinimides and maleimides. A class of central anticholinergic agents.

Authors:  B Karlèn; B Lindeke; S Lindgren; K G Svensson; R Dahlbom; D J Jenden; J E Giering
Journal:  J Med Chem       Date:  1970-07       Impact factor: 7.446

5.  N-(t-aminoalkynyl)-substituted pyrrolidones as oxotremorine antagonists.

Authors:  S Lindgren; A Lindquist; B Lindeke; U Svensson; B Karlén; R Dahlbem; M R Blair
Journal:  Experientia       Date:  1970-11-15
  5 in total
  1 in total

1.  Stereochemical requirements for central and peripheral muscarinic and antimuscarinic activity of some acetylenic compounds related to oxotremorine.

Authors:  R Dahlbom; D J Jenden; B Resul; B Ringdahl
Journal:  Br J Pharmacol       Date:  1982-06       Impact factor: 8.739
  1 in total

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