Literature DB >> 738393

Voltage-clamp analysis of the sodium and potassium currents in skeletal muscle fibres treated with 4-aminopyridine.

J Molgó.   

Abstract

External application of low concentrations of 4-aminopyridine blocks potassium currents without affecting sodium currents in pieces of single frog skeletal muscle fibres. The blockade of potassium currents was voltage-dependent, being partially relieved on depolarization.

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Year:  1978        PMID： 738393     DOI： 10.1007/bf01981414

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  An improved vaseline gap voltage clamp for skeletal muscle fibers.

Authors:  B Hille; D T Campbell
Journal:  J Gen Physiol       Date:  1976-03       Impact factor: 4.086

2.  The influence of potassium and chloride ions on the membrane potential of single muscle fibres.

Authors:  A L HODGKIN; P HOROWICZ
Journal:  J Physiol       Date:  1959-10       Impact factor: 5.182

3.  Aminopyridines and sparteine as inhibitors of membrane potassium conductance: effects on Myxicola giant axons and the lobster neuromuscular junction.

Authors:  C L Schauf; C A Colton; J S Colton; F A Davis
Journal:  J Pharmacol Exp Ther       Date:  1976-05       Impact factor: 4.030

4.  Ionic pores, gates, and gating currents.

Authors:  C M Armstrong
Journal:  Q Rev Biophys       Date:  1974-05       Impact factor: 5.318

5.  Proceedings: Selective inhibition of potassium current in the giant axon of the cockroach.

Authors:  M Pelhate; Y Pichon
Journal:  J Physiol       Date:  1974-10       Impact factor: 5.182

Review 6.  Chemicals as tools in the study of excitable membranes.

Authors:  T Narahashi
Journal:  Physiol Rev       Date:  1974-10       Impact factor: 37.312

7.  Block of potassium channels of the nodal membrane by 4-aminopyridine and its partial removal on depolarization.

Authors:  W Ulbricht; H H Wagner
Journal:  Pflugers Arch       Date:  1976-11-30       Impact factor: 3.657

8.  Interactions of aminopyridines with potassium channels of squid axon membranes.

Authors:  J Z Yeh; G S Oxford; C H Wu; T Narahashi
Journal:  Biophys J       Date:  1976-01       Impact factor: 4.033

9.  The effect of the tetraethylammonium ion on the delayed currents of frog skeletal muscle.

Authors:  P R Stanfield
Journal:  J Physiol       Date:  1970-07       Impact factor: 5.182

10.  Dynamics of aminopyridine block of potassium channels in squid axon membrane.

Authors:  J Z Yeh; G S Oxford; C H Wu; T Narahashi
Journal:  J Gen Physiol       Date:  1976-11       Impact factor: 4.086
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  4 in total

1.  The effects of 4-aminopyridine and tetrodotoxin on the release of acetylcholine from rat striatal slices.

Authors:  V Dolezal; S Tucek
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-06       Impact factor: 3.000

2.  Effective treatment of verapamil intoxication with 4-aminopyridine in the cat.

Authors:  S Agoston; E Maestrone; E J van Hezik; J M Ket; M C Houwertjes; D R Uges
Journal:  J Clin Invest       Date:  1984-05       Impact factor: 14.808

3.  Effects of 4-aminopyridine on inward rectifying and pacemaker currents of cardiac Purkinje fibres.

Authors:  P P Van Bogaert; D J Snyders
Journal:  Pflugers Arch       Date:  1982-09       Impact factor: 3.657

4.  Relation between action potential duration and mechanical activity on rat diaphragm fibers. Effects of 3,4-diaminopyridine and tetraethylammonium.

Authors:  O Delbono; B A Kotsias
Journal:  Pflugers Arch       Date:  1987-11       Impact factor: 3.657
  4 in total

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