Literature DB >> 738390

The antifertility action of alpha-chlorohydrin: enzyme inhibition by alpha-chlorohydrin phosphate.

P M Mashford, A R Jones.   

Abstract

Preparations of the enzymes glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase are shown to be inhibited by alpha-chlorohydrin phosphate (II) in a competitive and non-competitive manner, respectively. alpha-Chlorohydrin (I), glycidol and epi-chlorohydrin have no inhibitory activities suggesting that their antifertility actions are due to their metabolism in vivo to alpha-chlorohydrin phosphate.

Entities:  

Keywords:  Alcohols; Alpha-chlorohydrin; Biology; Clinical Research; Contraceptive Agents, Male; Enzyme Inhibitors; Enzymes; Enzymes And Enzyme Inhibitors; Evaluation; In Vitro; Ingredients And Chemicals; Organic Chemicals; Physiology; Research Methodology; Sperm Maturation Blocking Agents

Mesh：

Substances：

Year:  1978        PMID： 738390     DOI： 10.1007/bf01981408

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Identification of the biochemical lesion produced by alpha-chlorohydrin in spermatozoa.

Authors:  H Mohri; D A Suter; P D Brown-Woodman; I G White; D D Ridley
Journal:  Nature       Date:  1975-05-01       Impact factor: 49.962

2.  Proceedings: the molecular site of action of the anti-fertility agent, alpha-chlorohydrin, in ram spermatozoa.

Authors:  D A Suter; P D Brown-Woodman; H Mohri; I G White
Journal:  J Reprod Fertil       Date:  1975-05

3.  Antifertility intermediate.

Authors:  R J Ericsson; G A Youngdale
Journal:  Nature       Date:  1970-04-25       Impact factor: 49.962

4.  Effect of low doses of alpha-chlorohydrin on fertility and semen characteristics and binding of the drug of spermatozoa in swine.

Authors:  B G Crabo; K J Zimmerman; B Gustafson; M Holtman; T J Koh; E F Graham
Journal:  Int J Fertil       Date:  1975

5.  Effects of alpha-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat.

Authors:  E R Cooper; A R Jones; H Jackson
Journal:  J Reprod Fertil       Date:  1974-06

6.  Studies on the male anti-fertility drug 3-chloro-1,2-propanediol.

Authors:  P D Brown; I G White
Journal:  J Reprod Fertil       Date:  1973-02

7.  Reversible infertility in male swine fed -chlorohydrin.

Authors:  L A Johnson; V G Pursel
Journal:  J Anim Sci       Date:  1972-02       Impact factor: 3.159

8.  The entry of alpha-chlorohydrin into body fluids of male rats and its effect upon the incorporation of glycerol into lipids.

Authors:  E M Edwards; A R Jones; G M Waites
Journal:  J Reprod Fertil       Date:  1975-05

9.  Antifertility activity of 3-chloro-1, 2-propanediol (U-5897) on male rats.

Authors:  E Samojlik; M C Chang
Journal:  Biol Reprod       Date:  1970-04       Impact factor: 4.285

10.  Effects of alpha-chlorohydrin on the metabolism of testicular and epididymal spermatozoa of rams.

Authors:  E M Edwards; J L Dacheux; G M Waites
Journal:  J Reprod Fertil       Date:  1976-11
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  1 in total

1.  The antifertility action of alpha-chlorohydrin: metabolism by rat and boar sperm.

Authors:  A R Jones; D Stevenson; P Hutton; A G Dawson
Journal:  Experientia       Date:  1981-04-15
  1 in total

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