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Literature DB >> 738349

Investigation into the species-specific deacylation of penta-acetyl-gitoxin.

K O Haustein, C Pachaly, R Megges, P Franke.

Abstract

Penta-acetyl-gitoxin (PAG) shows species-specific deacylation to 16-acetyl-gitoxin (16 AG; I and III) or gitoxin (II and IV) by homogenates of liver and intestinal mucosa of man (I), rabbit (II), guinea-pig (III) and rat (IV), whereas it is degraded into tri- and tetra-acetates by homogenates of guinea-pig myocardium as well as by human blood and serum. The identity of the principal and chloroform-extractable metabolities in human urine after PAG administration with 16-AG has been demonstrated by mass spectrometry.

Entities: Chemical Species

Mesh：

Substances：
Acetyldigoxins
Digoxin

Year: 1978 PMID： 738349 DOI： 10.1007/bf00716384

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

9 in total

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Authors: H A KREBS
Journal: Biochim Biophys Acta Date: 1950-01

2. [Metabolism of helveticoside and helveticosol derivatives].

Authors: F Kaiser; W Schaumann
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1969

3. Studies on cardioactive steroids. II. Structure-activity relationships in the isolated guinea-pig heart.

Authors: K O Haustein; J Hauptmann
Journal: Pharmacology Date: 1974 Impact factor: 2.547

4. Studies on cardioactive steroids. I. Structure-activity relationships on the isolated atrium.

Authors: K O Haustein
Journal: Pharmacology Date: 1974 Impact factor: 2.547

5. [Study of cardiac glycosides on healthy subjects].

Authors: H Fiehring; I Assmann; H Schmidt; P Banse
Journal: Cor Vasa Date: 1973

6. Studies on digitalis glycosides. Gitoxin acetates. 2. Deacetylation of pentaacetylgitoxin with liver and heart homogenates.

Authors: J Morita; R Hirota; S Kimoto; T Mineshita
Journal: Chem Pharm Bull (Tokyo) Date: 1969-01 Impact factor: 1.645

7. Cardiac effects of 16-acetyl-gitoxin, the active glycoside after penta-acetyl-gitoxin administration.

Authors: K O Haustein; J Hauptmann; G Nowak
Journal: Acta Biol Med Ger Date: 1978

8. Pharmacokinetic investigations with 3H-penta-acetyl-gitoxin in volunteers and patients with respect to the occurrence of drug latentiation.

Authors: K O Haustein; C Pachaly; D Murawski
Journal: Int J Clin Pharmacol Biopharm Date: 1978-06

9. [The enzymatic decomposition of D-digitoxose, D-cymarose and L-thevetose from cardiac glycosides by liver sections].

Authors: F LAUTERBACH; K REPKE; D NITZ
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1960