Literature DB >> 7381694

Accumulation in the peripheral compartment of a linear two-compartment open model.

I Gonda, E S Harpur.   

Abstract

Accumulation factors for the peripheral compartment in a two-compartment open model are derived. These expressions are contrasted with some previously published statements concerning drug accumulation. The utility of the new indices of accumulation is illustrated by reference to studies of gentamicin tissue.uptake and its proposed relation to nephrotoxicity.

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Year:  1980        PMID： 7381694     DOI： 10.1007/bf01059451

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


  4 in total

1.  The theory of tracer experiments with 131I-labelled plasma proteins.

Authors:  C M MATTHEWS
Journal:  Phys Med Biol       Date:  1957-07       Impact factor: 3.609

2.  Gentamicin disposition and tissue accumulation on multiple dosing.

Authors:  J J Schentag; W J Jusko; J W Vance; T J Cumbo; E Abrutyn; M DeLattre; L M Gerbracht
Journal:  J Pharmacokinet Biopharm       Date:  1977-12

3.  Prescribing aids for gentamicin.

Authors:  G E Mawer; R Ahmad; S M Dobbs; J G McGough; S B Lucas; J A Tooth
Journal:  Br J Clin Pharmacol       Date:  1974-02       Impact factor: 4.335

4.  Drug therapy reviews: Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics--part 4: aminoglycosides.

Authors:  M Barza; R T Scheife
Journal:  Am J Hosp Pharm       Date:  1977-07
  4 in total
  3 in total

1.  The relation between plasma and tissue concentrations of antibiotics. Description of a method.

Authors:  H Mattie; J J Hoogeterp; J Hermans
Journal:  J Pharmacokinet Biopharm       Date:  1987-04

2.  Metformin kinetics in healthy subjects and in patients with diabetes mellitus.

Authors:  G T Tucker; C Casey; P J Phillips; H Connor; J D Ward; H F Woods
Journal:  Br J Clin Pharmacol       Date:  1981-08       Impact factor: 4.335

3.  Pharmacokinetics of amikacin in serum and in tissue contiguous with pressure sores in humans with spinal cord injury.

Authors:  J L Segal; S R Brunnemann; I M Eltorai
Journal:  Antimicrob Agents Chemother       Date:  1990-07       Impact factor: 5.191
  3 in total

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