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Literature DB >> 7379958

Voltage clamp method on single cardiac cells from adult rat heart.

A I Undrovinas, A V Yushmanova, S Hering, L V Rosenshtraukh.

Abstract

Voltage clamp experiments on isolated cardiac cells from adult rat hearts were carried out using an intracellular dialysis method. The fast inward current was recorded. Tetrodotoxin (TTX) at a concentration of 2.5 x 10(-7) g/ml blocked this current to 30% of its initial value. Inward maximal fast current density was calculated to be 0.14--0.7 mA/cm2.

Entities: Chemical Species

Mesh：

Substances：
Tetrodotoxin

Year: 1980 PMID： 7379958 DOI： 10.1007/bf01965808

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

9 in total

1. A quantitative description of membrane current and its application to conduction and excitation in nerve.

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Review 2. Heart: excitation and contraction.

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5. Voltage clamping of multicellular myocardial preparations: capabilities and limitations of existing methods.

Authors: G W Beeler; J A McGuigan
Journal: Prog Biophys Mol Biol Date: 1978 Impact factor: 3.667

6. A rapid method for the isolation of viable cardiac myocytes from adult rat.

Authors: J Rajs; M Sundberg; G B Sundby; N Danell; G Tornling; P Biberfeld; S W Jakobsson
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7. Surface characteristics of cells isolated from adult rat myocardium.

Authors: T Powell; E M Steen; V W Twist; N Woolf
Journal: J Mol Cell Cardiol Date: 1978-03 Impact factor: 5.000

8. Sodium channels in rabbit cardiac Purkinje fibres.

Authors: J J Colatsky; R W Tsien
Journal: Nature Date: 1979-03-15 Impact factor: 49.962

9. Sodium current in single heart muscle cells.

Authors: K S Lee; T A Weeks; R L Kao; N Akaike; A M Brown
Journal: Nature Date: 1979-03-15 Impact factor: 49.962

9 in total

8 in total

1. A comparative electrophysiological study of enzymatically isolated single cells and strips of frog ventricle.

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Authors: A Yatani; N Akaike
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7. Characterization of the fast sodium current in isolated rat myocardial cells: simulation of the clamped membrane potential.

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8. Active and passive electrical properties of single bullfrog atrial cells.

Authors: J R Hume; W Giles
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