Literature DB >> 7379921

Radiation protection of pronormoblasts and normoblasts by 2-mercaptopropionylglycine (MPG).

M R Saini, P U Devi.   

Abstract

The pronormoblasts and normoblasts in Swiss albino mice were found to be very sensitive to radiation and their percentage was reduced drastically after exposure to gamma-rays. The degree of damage increased with increase in radiation dose. MPG reduced the initial damage and brought about an early and fast recovery. It is concluded that the drug protects the stem cells and thereby reduces the depletion of the regenerating pool which causes a more efficient and accelerated recovery.

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Year:  1980        PMID： 7379921     DOI： 10.1007/bf01975140

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Quantitative studies on the depletion of the erythropoietic cells in the bone marrow of the irradiated rat.

Authors:  E V HULSE
Journal:  Br J Haematol       Date:  1957-10       Impact factor: 6.998

2.  Protective effect of 2-mercaptoethylguanidine on bone marrow cells x-irradiated in vitro.

Authors:  L H SMITH
Journal:  Exp Cell Res       Date:  1957-12       Impact factor: 3.905

3.  Effects of X-ray on lymphoid and hemopoietic tissues of albino mice.

Authors:  G BRECHER; K M ENDICOTT
Journal:  Blood       Date:  1948-11       Impact factor: 22.113

4.  Radiation protection of mouse liver by 2-mercaptopropionylglycine.

Authors:  M R Saini; B R Saharan; H C Bhartiya; P U Devi
Journal:  J Radiat Res       Date:  1977-08       Impact factor: 2.724

5.  The effect of radioprotective agents on stem cell recovery after irradiation.

Authors:  P V Vittorio; S Dziubalo-Blehm; E A Amey
Journal:  Radiat Res       Date:  1969-03       Impact factor: 2.841

6.  Radioprotective effect of 2-mercaptopropionylglycine on the small intestine of Swiss albino mice.

Authors:  P U Devi; M R Saini; A Verma; B R Saharan
Journal:  Indian J Exp Biol       Date:  1977-01       Impact factor: 0.818

7.  Radiation protection of bone marrow lymphocytes by 2-mercaptopropionylglycine (MPG).

Authors:  M R Saini; P U Devi; S S Yadav
Journal:  Experientia       Date:  1978-12-15

8.  Chemical protection of mouse spermatocytes against gamma-rays with 2-mercaptopropionylglycine.

Authors:  P U Devi; B R Saharan
Journal:  Experientia       Date:  1978-01-15
  8 in total
  1 in total

1.  Effect of 2-mercaptopropionylglycine (MPG) on thyroid function in sub-lethally irradiated mice.

Authors:  P Umi Devi; G C Jagetia
Journal:  Experientia       Date:  1981-03-15
  1 in total

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