Literature DB >> 7379857

Effects of phencyclidine on the spontaneous activity of monoaminergic neurons.

S N Raja, P G Guyenet.   

Abstract

Intravenous phencyclidine (PCP) increased the firing rate of a population of slow firing dopaminergic neurons recorded in the substantia nigra of chloral hydrate anesthetized rats. PCP also significantly reduced the potency of i.v. d-amphetamine to inhibit the firing of dopaminergic neurons. The drug produced little changes in the activity of serotonergic neurons of the dorsal raphe and consistently inhibited the firing of noradrenergic neurons in the locus coeruleus.

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Year:  1980        PMID： 7379857     DOI： 10.1016/0014-2999(80)90452-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  11 in total

1.  Phencyclidine increases forebrain monoamine metabolism in rats and monkeys: modulation by the isomers of HA966.

Authors:  J D Jentsch; J D Elsworth; D E Redmond; R H Roth
Journal:  J Neurosci       Date:  1997-03-01       Impact factor: 6.167

2.  Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex.

Authors:  W A Carlezon; R A Wise
Journal:  J Neurosci       Date:  1996-05-01       Impact factor: 6.167

3.  Homovanillic acid in rat caudate and prefrontal cortex following phencyclidine and amphetamine.

Authors:  M B Bowers; F J Hoffman
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

4.  Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization.

Authors:  S Murase; J M Mathé; J Grenhoff; T H Svensson
Journal:  J Neural Transm Gen Sect       Date:  1993

5.  Phencyclidine increases the affinity of dihydropyridine calcium channel antagonist binding in rat brain.

Authors:  G T Bolger; M F Rafferty; P Skolnick
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-09       Impact factor: 3.000

6.  Acute and chronic phencyclidine administration effects on the conversion of 3H-tryptophan to 3H-serotonin in rat forebrain.

Authors:  K M Johnson
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

7.  Differential electrophysiological and behavioral responses to optically active derivatives of phencyclidine.

Authors:  J Marwaha; M Palmer; B Hoffer; R Freedman; K C Rice; S Paul; P Skolnick
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-01       Impact factor: 3.000

8.  Antagonism of phencyclidine action by metaphit in rat cerebellar Purkinje neurons: an electrophysiological study.

Authors:  Y Wang; M Palmer; R Freedman; B Hoffer; M V Mattson; R A Lessor; K C Rice; A E Jacobson
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

9.  Decreased sensory responsiveness of noradrenergic neurons in the rat locus coeruleus following phencyclidine or dizocilpine (MK-801): role of NMDA antagonism.

Authors:  S Murase; M Nisell; J Grenhoff; T H Svensson
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

10.  Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons.

Authors:  Kareem S El Iskandrani; Chris A Oosterhof; Mostafa El Mansari; Pierre Blier
Journal:  J Psychopharmacol       Date:  2015-03-10       Impact factor: 4.153
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