| Literature DB >> 7379842 |
W J Nicklas, B Krespan, S Berl.
Abstract
The levels of ATP and amino acids were measured in rat cerebellar slices incubated in the presence of the neurotoxin, kainic acid (KA). 0.1--1 mM KA caused a significant decrease in tissue content of ATP, glutamate, aspartate and glutamine. The levels of glutamate and aspartate, but not glutamine, rose concomitantly in the incubation medium. The results are consistent with a multiaction mechanism for the neurotoxicity of KA.Entities:
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Year: 1980 PMID： 7379842 DOI： 10.1016/0014-2999(80)90278-2
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432