Literature DB >> 7379041

Differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by 1,2-dimethylhydrazine.

B A Diwan, K E Blackman.   

Abstract

Eight-week-old mice of 3 sublines of strain C57BL/6 were given s.c. injections of 1,2-dimethylhydrazine (DMH), once weekly for 10 weeks. The highest incidence (85%) of colorectal tumors occurred in C57BL/6N mice. Colorectal tumors occurred in 43% of C57BL/6J mice, while only 3 (10%) C57BL/6Ha mice developed these tumors. Possible factors responsible for the differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by DMH are discussed.

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Year:  1980        PMID: 7379041     DOI: 10.1016/0304-3835(80)90114-7

Source DB:  PubMed          Journal:  Cancer Lett        ISSN: 0304-3835            Impact factor:   8.679


  17 in total

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Review 2.  Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains.

Authors:  Steven Timmermans; Marc Van Montagu; Claude Libert
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3.  Disparities in auditory physiology and pathology between C57BL/6J and C57BL/6N substrains.

Authors:  Ann Kendall; Jochen Schacht
Journal:  Hear Res       Date:  2014-10-22       Impact factor: 3.208

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Journal:  Chem Res Toxicol       Date:  2011-05-24       Impact factor: 3.739

5.  High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.

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Journal:  J Cancer Res Clin Oncol       Date:  2003-05-13       Impact factor: 4.553

Review 6.  Mouse models for the study of colon carcinogenesis.

Authors:  Daniel W Rosenberg; Charles Giardina; Takuji Tanaka
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7.  Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus).

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Journal:  J Am Assoc Lab Anim Sci       Date:  2016       Impact factor: 1.232

8.  Substrains matter in phenotyping of C57BL/6 mice.

Authors:  Kazuyuki Mekada; Atsushi Yoshiki
Journal:  Exp Anim       Date:  2021-01-14

9.  Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross.

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Review 10.  Contemporary approaches for modifying the mouse genome.

Authors:  David J Adams; Louise van der Weyden
Journal:  Physiol Genomics       Date:  2008-06-17       Impact factor: 3.107

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