Literature DB >> 7379025

Microangiopathic anemia observed after treatment of epidermoid carcinoma with mitomycin C and 5-fluorouracil.

S C Gulati, P Sordillo, S Kempin, L Reich, G B Magill, E Scheiner, B Clarkson.   

Abstract

Two patients with epidermoid carcinoma treated with mitomycin-C (Mit-C) and 5-fluorouracil (5-FU) developed microangiopathic hemolytic anemia (MAHA), renal failure, and altered mental status. Patient 1 was free of metastatic disease, on maintenance Mit-C and 5-FU when MAHA changes appeared. Patient 2 had recurrent carcinoma in the pelvic area when MAHA changes appeared. In both patients, MAHA changes and neurologic function improved after exchange plasmapheresis. This is the first report of epidermoid carcinoma manifesting MAHA changes after chemotherapy. Speculation as to pathogenesis and appropriate therapy are discussed.

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Year:  1980        PMID： 7379025     DOI： 10.1002/1097-0142(19800501)45:9<2252::aid-cncr2820450906>3.0.co;2-n

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


  8 in total

1.  Clotting activation after blood transfusion in patients receiving 5-fluorouracil and mitomycin-C treatment.

Authors:  G Agnelli; P Gresele; G G Nenci
Journal:  Cancer Chemother Pharmacol       Date:  1981       Impact factor: 3.333

2.  Adriamycin, vinblastine and mitomycin C as second-line chemotherapy in advanced breast cancer.

Authors:  A Sulkes; E Gez; M R Pfeffer; R Catane; R Isacson; S Biran
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

Review 3.  Adverse haematological complications of anticancer drugs. Clinical presentation, management and avoidance.

Authors:  D C Bodensteiner; G C Doolittle
Journal:  Drug Saf       Date:  1993-03       Impact factor: 5.606

4.  Mitomycin-induced hemolytic uremic kidney. An experimental model in the rat.

Authors:  V Cattell
Journal:  Am J Pathol       Date:  1985-10       Impact factor: 4.307

5.  Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.

Authors:  J van der Meer; E G de Vries; R Vriesendorp; P H Willemse; A J Donker; J G Aalders
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553

6.  Gastric carcinoma and thrombotic thrombocytopenic purpura: association with plasma immune complex concentrations.

Authors:  S E Zimmerman; F P Smith; T M Phillips; R J Coffey; P S Schein
Journal:  Br Med J (Clin Res Ed)       Date:  1982-05-15

Review 7.  Anticancer drug-induced kidney disorders.

Authors:  P E Kintzel
Journal:  Drug Saf       Date:  2001-01       Impact factor: 5.228

8.  Elevated reticulocyte count--a clue to the diagnosis of haemolytic-uraemic syndrome (HUS) associated with gemcitabine therapy for metastatic duodenal papillary carcinoma: a case report.

Authors:  S Serke; H Riess; H Oettle; D Huhn
Journal:  Br J Cancer       Date:  1999-03       Impact factor: 7.640
  8 in total

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