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Literature DB >> 7378653

Modulation by acetylcholine of the electrically-evoked release of [3H]-acetylcholine from the ileum of the guinea-pig.

Abstract

1 Acetylcholine (ACh) stores within neurones of the myenteric plexus of the guinea-pig were labelled with [3H]-choline and the influence of unlabelled ACh, atropine, or atropine and unlabelled ACh on the electrically-evoked output of [3H]-ACh was evaluated. 2 Electrical transmural stimulation (5 Hz) of the ileum led to an increase in the output of [3H]-ACh over that released spontaneously. Superfusion with unlabelled ACh (6.8 microM) caused a marked reduction in the release of [3H]-ACh which was reversed by atropine (3.5 microM). Atropine itself had no effect on the electrically-evoked [3H]-ACh. 3 These experiments provide further evidence for the existence in the guinea-pig ileum of neuronal muscarinic receptors for ACh subserving an inhibitory role on transmitter release.

Entities: Chemical Species

Mesh：

Substances：
Choline
Acetylcholine

Year: 1980 PMID： 7378653 PMCID： PMC2044170 DOI： 10.1111/j.1476-5381.1980.tb10894.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

12 in total

1. Muscarinic feedback inhibition of acetylcholine release from the myenteric plexus in the quinea pig ileum and its status after chronic exposure to morphine.

Authors: J Sawynok; K Jhamandas
Journal: Can J Physiol Pharmacol Date: 1977-08 Impact factor: 2.273

2. Depression of acetylcholine release from cerebral cortical slices by cholinesterase inhibition and by oxotremorine.

Authors: J C Szerb; G T Somogyi
Journal: Nat New Biol Date: 1973-01-24

3. Presynaptic inhibition of acetylcholine release from cholinergic neurones in the myenteric plexus of the guinea-pig ileum [proceedings].

Authors: P Fosbraey; E S Johnson
Journal: Br J Pharmacol Date: 1978-03 Impact factor: 8.739

4. Modulation by oxotremorine and atropine of acetylcholine release evoked by electrical stimulation of the myenteric plexus of the guinea-pig ileum.

Authors: H Kilbinger
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-11 Impact factor: 3.000

5. Effect of external ACh and of atropine on 14C-ACh synthesis and release in rat cortical slices.

Authors: J P Rospars; P Lefresne; J C Beaujouan; J Glowinski
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-11 Impact factor: 3.000

6. Storage and release of labelled acetylcholine in the myenteric plexus of the guinea-pig ileum.

Authors: J C Szerb
Journal: Can J Physiol Pharmacol Date: 1976-02 Impact factor: 2.273

7. Inhibition by oxotremorine of acetylcholine resting release from guinea pig-ileum longitudinal muscle strips.

Authors: H Kilbinger; P Wagner
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

8. Muscarinic modulation of acetylcholine release evoked by dimethylphenylpiperazinium and high potassium from guinea-pig myenteric plexus.

Authors: P Dzieniszewski; H Kilbinger
Journal: Eur J Pharmacol Date: 1978-08-15 Impact factor: 4.432

9. Stimulating action of atropine on the release of acetylcholine by rat cerebral cortex in vitro.

Authors: R L Polak
Journal: Br J Pharmacol Date: 1971-04 Impact factor: 8.739

10. The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips.

Authors: W D Paton; M A Zar
Journal: J Physiol Date: 1968-01 Impact factor: 5.182

8 in total

1. Prevention of guanine nucleotide-induced reductions in muscarinic agonist binding to rabbit ileal submucosal membranes by lidamidine and tetracaine.

Authors: D Bleakman; R J Naftalin
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1988-04 Impact factor: 3.000

Modulation by acetylcholine of the electrically-evoked release of [3H]-acetylcholine from the ileum of the guinea-pig.

1. Muscarinic feedback inhibition of acetylcholine release from the myenteric plexus in the quinea pig ileum and its status after chronic exposure to morphine.

2. Depression of acetylcholine release from cerebral cortical slices by cholinesterase inhibition and by oxotremorine.

3. Presynaptic inhibition of acetylcholine release from cholinergic neurones in the myenteric plexus of the guinea-pig ileum [proceedings].

4. Modulation by oxotremorine and atropine of acetylcholine release evoked by electrical stimulation of the myenteric plexus of the guinea-pig ileum.

5. Effect of external ACh and of atropine on 14C-ACh synthesis and release in rat cortical slices.

6. Storage and release of labelled acetylcholine in the myenteric plexus of the guinea-pig ileum.

7. Inhibition by oxotremorine of acetylcholine resting release from guinea pig-ileum longitudinal muscle strips.

8. Muscarinic modulation of acetylcholine release evoked by dimethylphenylpiperazinium and high potassium from guinea-pig myenteric plexus.

9. Stimulating action of atropine on the release of acetylcholine by rat cerebral cortex in vitro.

10. The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips.

1. Prevention of guanine nucleotide-induced reductions in muscarinic agonist binding to rabbit ileal submucosal membranes by lidamidine and tetracaine.

2. Pre- and postsynaptic effects of muscarinic agonists in the guinea-pig ileum.

3. Epithelium-derived inhibition of [3H]acetylcholine release from the isolated guinea-pig trachea.

4. Facilitatory and inhibitory muscarine receptors on the rat phrenic nerve: effects of pirenzepine and dicyclomine.

5. Muscarine receptors on the rat phrenic nerve, evidence for positive and negative muscarinic feedback mechanisms.

6. Choline inhibits acetylcholine release via presynaptic muscarine receptors.

7. Presynaptic muscarinic receptors inhibiting active acetylcholine release in the bullfrog sympathetic ganglion.

8. The effects of atropine and oxotremorine on acetylcholine release in rat phrenic nerve-diaphragm preparations.