Literature DB >> 7378635

Inhibition of the acetylcholine receptor by histrionicotoxin.

R Anwyl, T Narahashi.   

Abstract

1 The action of C5-decahydrohistrionicotoxin (C5-HTX) has been investigated on the extrajunctional acetylcholine (ACh) receptors of denervated rat muscle. 2 C5-HTX causes both a rapid and slow reduction in amplitude of iontophoretic ACh potentials evoked at all frequencies from the extrajunctional receptors. 3 C5-HTX also causes a time-dependent inhibition of the iontophoretic potentials evoked at frequencies greater than 0.02 Hz. This inhibition was observed either alone or superimposed upon desensitization, and may be caused by a similar mechanism to desensitization.

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Year:  1980        PMID： 7378635      PMCID： PMC2044238          DOI： 10.1111/j.1476-5381.1980.tb10851.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Junctional and extra-junctional acetylcholine receptors in skeletal muscle fibres.

Authors:  R MILEDI
Journal:  J Physiol       Date:  1960-04       Impact factor: 5.182

2.  Studies on the effect of histrionicotoxin on the monocellular electroplax from Electrophorus electricus and on the binding of (3H)acetylcholine to membrane fragments from Torpedo marmorata.

Authors:  G Kato; J P Changeux
Journal:  Mol Pharmacol       Date:  1976-01       Impact factor: 4.436

3.  Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents.

Authors:  E X Albuquerque; P W Gage
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

4.  Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor.

Authors:  A T Eldefrawi; M E Eldefrawi; E X Albuquerque; A C Oliveira; N Mansour; M Adler; J W Daly; G B Brown; W Burgermeister; B Witkop
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

5.  Distinct protein components from Torpedo marmorata membranes carry the acetylcholine receptor site and the binding site for local anesthetics and histrionicotoxin.

Authors:  A Sobel; T Heidmann; J Hofler; J P Changeux
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

6.  Effect of histrionicotoxin on the ionic conductance modulator of the cholinergic receptor: a quantitative analysis of the end-plate current.

Authors:  E X Albuquerque; K Kuba; J Daly
Journal:  J Pharmacol Exp Ther       Date:  1974-05       Impact factor: 4.030

7.  Acetylcholine receptor and ion conductance modulator sites at the murine neuromuscular junction: evidence from specific toxin reactions.

Authors:  E X Albuquerque; E A Barnard; T H Chiu; A J Lapa; J O Dolly; S E Jansson; J Daly; B Witkop
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

8.  Binding of perhydro-histrionicotoxin to the postsynaptic membrane of skeletal muscle in relation to its blockage of acetylcholine-induced depolarization.

Authors:  J O Dolly; E X Albuquerque; J Sarvey; B Mallick; E A Barnard
Journal:  Mol Pharmacol       Date:  1977-01       Impact factor: 4.436

9.  Histrionicotoxin enhances agonist-induced desensitization of acetylcholine receptor.

Authors:  W Burgermeister; W A Catterall; B Witkop
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205
  9 in total

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