Literature DB >> 7378272

Effects of monocytopenia and anticoagulation in experimental Streptococcus sanguis endocarditis.

L Thörig, J Thompson, F Eulderink, J J Emeis, R Van Furth.   

Abstract

The role of blood monocytes in the attachment of streptococci to endocardial vegetations was investigated in an experimental Streptococcus sanguis endocarditis by depletion of blood monocytes with the cytostatic drug VP 16-213 alone and combined with anticoagulant treatment with warfarin sodium. The numbers of streptococci in the vegetations of control, monocytopenic, and monocytopenic/anticoagulated rabbits were comparable. In the vegetations streptococci were found mainly in areas free of phagocytic cells. It is concluded that streptococci do not have to be phagocytosed by monocytes in the circulation before being deposited on the surface of endocardial vegetations. Even the vegetations of intensively anticoagulated/monocytopenic rabbits showed colonies of streptococci embedded in polymerized fibrin and cellular material, this matrix possibly being held together by streptococcal dextran.

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Year:  1980        PMID： 7378272      PMCID： PMC2041555     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  14 in total

1.  Experimental bacterial endocarditis. IV. Structure and evolution of very early lesions.

Authors:  D T Durack
Journal:  J Pathol       Date:  1975-02       Impact factor: 7.996

Review 2.  VM 26 and VP 16-213: a comparative analysis.

Authors:  M Rozencweig; D D Von Hoff; J E Henney; F M Muggia
Journal:  Cancer       Date:  1977-07       Impact factor: 6.860

Review 3.  Pathoanatomic, pathophysiologic and clinical correlations in endocarditis (first of two parts).

Authors:  L Weinstein; J J Schlesinger
Journal:  N Engl J Med       Date:  1974-10-17       Impact factor: 91.245

Review 4.  Infective endocarditis--1973.

Authors:  L Weinstein; R H Rubin
Journal:  Prog Cardiovasc Dis       Date:  1973 Nov-Dec       Impact factor: 8.194

5.  Experimental bacterial endocarditis. I. Colonization of a sterile vegetation.

Authors:  D T Durack; P B Beeson
Journal:  Br J Exp Pathol       Date:  1972-02

6.  [Morphologic demonstration of fibrin monomers in histogic sections].

Authors:  U Bleyl; H Sebening; W Kuhn
Journal:  Thromb Diath Haemorrh       Date:  1969-08-31

7.  Clinical investigation of a new podophyllum derivative, epipodophyllotoxin, 4'-demethyl-9-(4,6-O-2-thenylidene- -D-glucopyranoside) (NSC-122819), in patients with malignant lymphomas and solid tumors.

Authors:  P Dombernowsky; N I Nissen; V Larsen
Journal:  Cancer Chemother Rep       Date:  1972-02

8.  The antithrombotic effects of sodium heparin and sodium warfarin.

Authors:  J C Hoak; W E Connor; E D Warner
Journal:  Arch Intern Med       Date:  1966-01

9.  Effect of warfarin on the induction and course of experimental endocarditis.

Authors:  J Thompson; F Eulderink; H Lemkes; R van Furth
Journal:  Infect Immun       Date:  1976-12       Impact factor: 3.441

10.  Warfarin sodium in prevention of deep venous thrombosis and pulmonary embolism in patients with fractured neck of femur.

Authors:  G K Morris; J R Mitchell
Journal:  Lancet       Date:  1976-10-23       Impact factor: 79.321
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  15 in total

1.  Endocarditis-associated oral streptococci promote rapid differentiation of monocytes into mature dendritic cells.

Authors:  Chin-Lo Hahn; Harvey A Schenkein; John G Tew
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

2.  Stimulation of monocyte tissue factor expression in an in vitro model of bacterial endocarditis.

Authors:  M J Bancsi; J Thompson; R M Bertina
Journal:  Infect Immun       Date:  1994-12       Impact factor: 3.441

3.  Role of granulocytes in experimental Streptococcus sanguis endocarditis.

Authors:  M J Meddens; J Thompson; F Eulderink; W C Bauer; H Mattie; R van Furth
Journal:  Infect Immun       Date:  1982-04       Impact factor: 3.441

4.  Exopolysaccharide production by viridans streptococci in experimental endocarditis.

Authors:  J Mills; L Pulliam; L Dall; J Marzouk; W Wilson; J W Costerton
Journal:  Infect Immun       Date:  1984-01       Impact factor: 3.441

5.  Role of granulocytes in the prevention and therapy of experimental Streptococcus sanguis endocarditis in rabbits.

Authors:  M J Meddens; J Thompson; H Mattie; R van Furth
Journal:  Antimicrob Agents Chemother       Date:  1984-02       Impact factor: 5.191

6.  Role of granulocytes and monocytes in experimental Escherichia coli endocarditis.

Authors:  M J Meddens; J Thompson; W C Bauer; R van Furth
Journal:  Infect Immun       Date:  1984-02       Impact factor: 3.441

7.  Effect of irradiation, cyclophosphamide, and etoposide (VP-16) on number of peripheral blood and peritoneal leukocytes in mice under normal conditions and during acute inflammatory reaction.

Authors:  J W van't Wout; I Linde; P C Leijh; R van Furth
Journal:  Inflammation       Date:  1989-02       Impact factor: 4.092

8.  The role of bacterial adherence in the pathogenesis of infective endocarditis.

Authors:  J Thompson; M J Meddens; L Thörig; R van Furth
Journal:  Infection       Date:  1982       Impact factor: 3.553

9.  Role of granulocytes and monocytes in experimental Staphylococcus epidermidis endocarditis.

Authors:  M J Meddens; J Thompson; W C Bauer; J Hermans; R van Furth
Journal:  Infect Immun       Date:  1983-07       Impact factor: 3.441

10.  Influence of monocytes and antibiotic treatment on tissue factor activity of endocardial vegetations in rabbits infected with Streptococcus sanguis.

Authors:  M J Bancsi; M H Veltrop; R M Bertina; J Thompson
Journal:  Infect Immun       Date:  1996-02       Impact factor: 3.441
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