Literature DB >> 7378106

A highly topically active corticosteroid. Preliminary report.

Y Mizushima, H Miyake, K Fujiwara, N Ono, K Takikawa.   

Abstract

The local anti-inflammatory effects of a synthetic corticosteroid, 17 alpha, 21-diacetory-2-bromo-6 beta, 9 alpha-difluoro-11 beta-hydroxy-1,4,-pregnadiene-3,20-dione (F-2), were evaluated by granuloma and granuloma pouch method. F-2 had an intensive and probably persistent topical anti-inflammatory activity. The systemic effects of F-2 were evaluated by measuring the thymus and adrenal gland weight. F-2 did not induce significant systemic effects at as high a dose as 125 times the effective dose.

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Year:  1980        PMID： 7378106

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  3 in total

1.  Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium.

Authors:  Eijiro Horisawa; Katsuaki Kubota; Izumi Tuboi; Keiichi Sato; Hiromitsu Yamamoto; Hirofumi Takeuchi; Yoshiaki Kawashima
Journal:  Pharm Res       Date:  2002-02       Impact factor: 4.200

2.  Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit.

Authors:  Eijiro Horisawa; Tsuyoshi Hirota; Satoko Kawazoe; Jun Yamada; Hiromitsu Yamamoto; Hirofumi Takeuchi; Yoshiaki Kawashima
Journal:  Pharm Res       Date:  2002-04       Impact factor: 4.200

3.  Could albumin affect the self-assembling properties of a block co-polymer system and drug release? An in-vitro study.

Authors:  Diego R Perinelli; Giulia Bonacucina; Stefania Pucciarelli; Marco Cespi; Luca Casettari; Valeria Polzonetti; Francesco Martino Carpi; Giovanni F Palmieri
Journal:  Pharm Res       Date:  2014-09-19       Impact factor: 4.200
  3 in total

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