Literature DB >> 7378063

5,6-epoxyretinoic acid is a physiological metabolite of retinoic acid in the rat.

A M McCormick, J L Napoli, S Yoshizawa, H F DeLuca.   

Abstract

5,6-Epoxyretinoic acid was detected in small intestine, kidney, liver, testes and serum of vitamin A-deficient rats 3 h after a single physiological dose of [3H]retinoic acid. The maximum concentration of 5,6-epoxide in intestinal mucosa was observed 3 h after intrajugular administration of retinoic acid. However, at 7 h post administration, no 5,6-epoxyretinoic acid was detected in mucosa, demonstrating the rapid intestinal metabolism or excretion of this metabolite. No 5,6-epoxy[3H]retinoic acid was detected in mucosa, liver or serum of retinoic acid-repleted rats 3 h after administration of 2 micrograms of [3H]retinoic acid.

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Year:  1980        PMID： 7378063      PMCID： PMC1161599          DOI： 10.1042/bj1860475

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  Isolation and identification of three major metabolites of retinoic acid from rat feces.

Authors:  R Hänni; F Bigler
Journal:  Helv Chim Acta       Date:  1977-04-20       Impact factor: 2.164

2.  Identification of 5,8-oxyretinoic acid isolated from small intestine of vitamin A-deficient rats dosed with retinoic acid.

Authors:  J L Napoli; A M McCormick; H K Schnoes; H F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

Review 3.  Metabolism of vitamin A and the determination of vitamin A status.

Authors:  P Rietz; O Wiss; F Weber
Journal:  Vitam Horm       Date:  1974       Impact factor: 3.421

4.  Vitamin A and ribonucleic acid synthesis in rat intestine.

Authors:  M Zile; H F Deluca
Journal:  Arch Biochem Biophys       Date:  1970-09       Impact factor: 4.013

5.  Vitamin A and protein synthesis by rat intestinal mucosa.

Authors:  L De Luca; E P Little; G Wolf
Journal:  J Biol Chem       Date:  1969-02-25       Impact factor: 5.157

6.  Isolation and identification of 5, 6-epoxyretinoic acid: a biologically active metabolite of retinoic acid.

Authors:  A M McCormick; J L Napoli; H K Schnoes; H F DeLuca
Journal:  Biochemistry       Date:  1978-09-19       Impact factor: 3.162

7.  Origin of some derivatives of retinoic acid found in rat bile.

Authors:  K Lippel; J A Olson
Journal:  J Lipid Res       Date:  1968-09       Impact factor: 5.922

8.  Liquid-gel partition chromatography of vitamin A compounds; formation of retinoic acid from retinyl acetate in vivo.

Authors:  Y L Ito; M Zile; H Ahrens; H F DeLuca
Journal:  J Lipid Res       Date:  1974-09       Impact factor: 5.922

9.  Pathways of absorption of retinal and retinoic acid in the rat.

Authors:  N H Fidge; T Shiratori; J Ganguly; D S Goodman
Journal:  J Lipid Res       Date:  1968-01       Impact factor: 5.922

10.  PREPARATION AND PROPERTIES OF 5,6-MONOEPOXYVITAMIN A ACETATE, 5,6-MONOEPOXYVITAMIN A ALCOHOL, 5,6-MONOEPOXYVITAMIN A ALDEHYDE AND THEIR CORRESPONDING 5,8-MONOEPOXY (FURANOID) COMPOUNDS.

Authors:  F B JUNGALWALA; H R CAMA
Journal:  Biochem J       Date:  1965-04       Impact factor: 3.857
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  5 in total

1.  Uptake and metabolism of β-apo-8'-carotenal, β-apo-10'-carotenal, and β-apo-13-carotenone in Caco-2 cells.

Authors:  Boluwatiwi O Durojaye; Kenneth M Riedl; Robert W Curley; Earl H Harrison
Journal:  J Lipid Res       Date:  2019-03-06       Impact factor: 5.922

2.  One-Step, Low-Cost, Operator-Friendly, and Scalable Procedure to Synthetize Highly Pure N-(4-ethoxyphenyl)-retinamide in Quantitative Yield without Purification Work-Up.

Authors:  Silvana Alfei; Guendalina Zuccari
Journal:  Molecules       Date:  2022-06-06       Impact factor: 4.927

3.  Synthesis and metabolism of all-trans-[11-3H]retinyl beta-glucuronide in rats in vivo.

Authors:  A B Barua; R O Batres; J A Olson
Journal:  Biochem J       Date:  1988-06-01       Impact factor: 3.857

4.  Metabolism in vivo of all-trans-[11-3H]retinoic acid after an oral dose in rats. Characterization of retinoyl beta-glucuronide in the blood and other tissues.

Authors:  A B Barua; D B Gunning; J A Olson
Journal:  Biochem J       Date:  1991-07-15       Impact factor: 3.857

5.  Metabolism of retinoic acid in vivo in the vitamin A-deficient rat.

Authors:  D P Silva; H F DeLuca
Journal:  Biochem J       Date:  1982-07-15       Impact factor: 3.857
  5 in total

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