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Literature DB >> 7375939

Cross-linking of lens crystallins in a photodynamic system: a process mediated by singlet oxygen.

Abstract

In a dye-sensitized photooxidation system, lens crystallin polypeptides become cross-linked, and a blue fluorescence that is associated with the proteins is produced. These changes are similar to those seen in vivo in the aging human lens. Evidence implicating singlet oxygen as the causative agent of the effects in vitro is presented, and the possibility that this species may play a role in aging and cataractogenesis in vivo is discussed.

Entities: Chemical Species

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Year: 1980 PMID： 7375939 DOI： 10.1126/science.7375939

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

18 in total

1. Protection against UVB inactivation (in vitro) of rat lens enzymes by natural antioxidants.

Authors: G B Reddy; K S Bhat
Journal: Mol Cell Biochem Date: 1999-04 Impact factor: 3.396

2. Detection and prevention of ocular phototoxicity of ciprofloxacin and other fluoroquinolone antibiotics.

Authors: Baozhong Zhao; Colin F Chignell; Mustapha Rammal; Frank Smith; Mary G Hamilton; Usha P Andley; Joan E Roberts
Journal: Photochem Photobiol Date: 2010-06-01 Impact factor: 3.421

3. Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.

Authors: J Mårtensson; R Steinherz; A Jain; A Meister
Journal: Proc Natl Acad Sci U S A Date: 1989-11 Impact factor: 11.205

4. Imaging intracellular viscosity of a single cell during photoinduced cell death.

Authors: Marina K Kuimova; Stanley W Botchway; Anthony W Parker; Milan Balaz; Hazel A Collins; Harry L Anderson; Klaus Suhling; Peter R Ogilby
Journal: Nat Chem Date: 2009-03-15 Impact factor: 24.427

5. Müller cell alterations from long-term ambient fluorescent light exposure in monkeys: light and electron microscopic, fluorescein and lipofuscin study.

Authors: D K Berler
Journal: Trans Am Ophthalmol Soc Date: 1989

Cross-linking of lens crystallins in a photodynamic system: a process mediated by singlet oxygen.

1. Protection against UVB inactivation (in vitro) of rat lens enzymes by natural antioxidants.

2. Detection and prevention of ocular phototoxicity of ciprofloxacin and other fluoroquinolone antibiotics.

3. Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.

4. Imaging intracellular viscosity of a single cell during photoinduced cell death.

5. Müller cell alterations from long-term ambient fluorescent light exposure in monkeys: light and electron microscopic, fluorescein and lipofuscin study.

6. alpha-Crystallin acting as a molecular chaperonin against photodamage by UV irradiation.

7. Effects of near ultraviolet radiation on the lens and retina.

8. Hydrogen peroxide and hydroxyl radical formation by methylene blue in the presence of ascorbic acid.

9. Biochemical evidence for membrane disintegration in human cataracts.

10. Covalent Ras Dimerization on Membrane Surfaces through Photosensitized Oxidation.