Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Secondary regulatory sites in rat liver cholesterol biosynthesis: role of 5-pyrophosphomevalonate decarboxylase.

Literature DB >> 7374372

Secondary regulatory sites in rat liver cholesterol biosynthesis: role of 5-pyrophosphomevalonate decarboxylase.

Abstract

The activity of 5-pyrophosphomevalonate decarboxylase in 43,000 g supernatant fractions from livers and kidneys of male adult rats has been determined. Enzyme activity in liver is significantly increased when rats are fed a diet containing 3% cholestyramine (268% of control rats) and decreased when fed a diet containing 2% cholesterol (25% of control rats). No circadian rhythm of enzyme activity is found in liver or kidneys. These results show that variations in hepatic cholesterogenesis affect the activity of 5-pyrophosphomevalonate decarboxylase in a similar way as other enzymes involved in the biosynthesis of cholesterol.

Entities: Chemical Species

Mesh：

Substances：

Year: 1980 PMID： 7374372 DOI： 10.1007/bf02540970

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

14 in total

1. Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.

Authors: S Balasubramaniam; J L Goldstein; M S Brown
Journal: Proc Natl Acad Sci U S A Date: 1977-04 Impact factor: 11.205

2. Decarboxylation of mevalonate pyrophosphate is one rate-limiting step in hepatic cholesterol synthesis in suckling and weaned rats.

Authors: C K Ramachandran; S N Shah
Journal: Biochem Biophys Res Commun Date: 1976-03-08 Impact factor: 3.575

3. Studies on mevalonate kinase, phosphomevalonate kinase and pyrophosphomevalonate decarboxylase in developing rat brain.

Authors: C K Ramachandran; S N Shah
Journal: J Neurochem Date: 1977-04 Impact factor: 5.372

4. Metabolism of mevalonic acid to phosphorylated derivatives in Chlorella.

Authors: A Linares; M D Suarez; E Garcia-Peregrin
Journal: Biochem Biophys Res Commun Date: 1977-08-08 Impact factor: 3.575

5. The effects of fasting, refeeding, and time of day on the levels of enzymes effecting the conversion of -hydroxy- -methylglutaryl-coenzyme A to squalene.

Authors: L L Slakey; M C Craig; E Beytia; A Briedis; D H Feldbruegge; R E Dugan; A A Qureshi; C Subbarayan; J W Porter
Journal: J Biol Chem Date: 1972-05-25 Impact factor: 5.157

6. Regulation of 3-hydroxy-3-methylglutarate and mevalonate biosynthesis by rat liver homogenates. Effects of fasting, cholesterol feeding, and triton administration.

Authors: L W White; H Rudney
Journal: Biochemistry Date: 1970-06-23 Impact factor: 3.162

7. Regulation of cholesterol biosynthesis in rat liver: diurnal changes of activity and influence of bile acids.

Authors: P Back; B Hamprecht; F Lynen
Journal: Arch Biochem Biophys Date: 1969-08 Impact factor: 4.013

8. Rhythmic activity of utilization of mevalonate for biogenesis of cholesterol.

Authors: C S Bhat; T Ramasarma
Journal: Biochem Biophys Res Commun Date: 1977-01-24 Impact factor: 3.575

9. Sex differences in the sterol and nonsterol metabolism of mevalonate.

Authors: M H Wiley; M M Howton; M D Siperstein
Journal: J Biol Chem Date: 1979-02-10 Impact factor: 5.157

10. Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds.

Authors: C Shama Bhat; T Ramasarma
Journal: Biochem J Date: 1979-07-01 Impact factor: 3.857

8 in total

8. Inhibition of brain and liver 3-hydroxy-3-methylglutaryl-CoA reductase and mevalonate-5-pyrophosphate decarboxylase in experimental hyperphenylalaninemia.

Authors: M Castillo; M F Zafra; E Garcia-Peregrin
Journal: Neurochem Res Date: 1988-06 Impact factor: 3.996

8 in total

Secondary regulatory sites in rat liver cholesterol biosynthesis: role of 5-pyrophosphomevalonate decarboxylase.

1. Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.

2. Decarboxylation of mevalonate pyrophosphate is one rate-limiting step in hepatic cholesterol synthesis in suckling and weaned rats.

3. Studies on mevalonate kinase, phosphomevalonate kinase and pyrophosphomevalonate decarboxylase in developing rat brain.

4. Metabolism of mevalonic acid to phosphorylated derivatives in Chlorella.

5. The effects of fasting, refeeding, and time of day on the levels of enzymes effecting the conversion of -hydroxy- -methylglutaryl-coenzyme A to squalene.

6. Regulation of 3-hydroxy-3-methylglutarate and mevalonate biosynthesis by rat liver homogenates. Effects of fasting, cholesterol feeding, and triton administration.

7. Regulation of cholesterol biosynthesis in rat liver: diurnal changes of activity and influence of bile acids.

8. Rhythmic activity of utilization of mevalonate for biogenesis of cholesterol.

9. Sex differences in the sterol and nonsterol metabolism of mevalonate.

10. Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds.

1. Effect of clofibrate on brain mevalonate-5-pyrophosphate decarboxylase.

2. Effect of lipid content of diet on cholesterol content and cholesterogenic enzymes of European eel liver.

3. Relationship between changes in free cholesterol and pyrophosphomevalonate decarboxylase activity during myelination.

4. The effects of phosphate on the biosynthesis of cholesterol in rat liver homogenates.

5. Characterization of mevalonate metabolism in the sea bass (Dicentrarchus labrax L) liver.

6. Effect of phenylalanine derivatives on the main regulatory enzymes of hepatic cholesterogenesis.

7. Further studies on mevalonate phosphorylation in neonatal chick brain.

8. Inhibition of brain and liver 3-hydroxy-3-methylglutaryl-CoA reductase and mevalonate-5-pyrophosphate decarboxylase in experimental hyperphenylalaninemia.