Literature DB >> 7372626

Structural studies on the carbohydrate portion of human antithrombin III.

L E Franzén, S Svensson, O Larm.   

Abstract

Human antithrombin III has been shown to contain four identical N-glycosidically linked carbohydrate chain per molecule. These carbohydrate chains have been investigated by sugar and methylation analysis before and after removal of N-acetylneuraminic acid residues. The chains have been further investigated by Smith degradation, trifluoroacetolytic degradation, and degradation after chromium trioxide oxidation. As a result of these studies, the following structures is proposed for the carbohydrate chains in human antithrombin III: (formula: see text). NeuNAc, N-acetylneuraminic acid; Galp, galactopyranose; GlcNAcp, 2-acetamido-2-deoxyglucopyranose; Manp, mannopyranose are the abbreviations used in the structure.

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Year:  1980        PMID： 7372626

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  19 in total

1.  Decreased affinity of recombinant antithrombin for heparin due to increased glycosylation.

Authors:  I Björk; K Ylinenjärvi; S T Olson; P Hermentin; H S Conradt; G Zettlmeissl
Journal:  Biochem J       Date:  1992-09-15       Impact factor: 3.857

Review 2.  Carbohydrate analysis of glycoproteins. A review.

Authors:  K B Lee; D Loganathan; Z M Merchant; R J Linhardt
Journal:  Appl Biochem Biotechnol       Date:  1990-01       Impact factor: 2.926

Review 3.  Mechanism of the anticoagulant action of heparin.

Authors:  I Björk; U Lindahl
Journal:  Mol Cell Biochem       Date:  1982-10-29       Impact factor: 3.396

4.  Elimination of glycosylation heterogeneity affecting heparin affinity of recombinant human antithrombin III by expression of a beta-like variant in baculovirus-infected insect cells.

Authors:  E Ersdal-Badju; A Lu; X Peng; V Picard; P Zendehrouh; B Turk; I Björk; S T Olson; S C Bock
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

5.  Mitogenic leukoagglutinin from Phaseolus vulgaris binds to a pentasaccharide unit in N-acetyllactosamine-type glycoprotein glycans.

Authors:  S Hammarström; M L Hammarström; G Sundblad; J Arnarp; J Lönngren
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

6.  Analysis of the N-glycans of recombinant human Factor IX purified from transgenic pig milk.

Authors:  Geun-Cheol Gil; William H Velander; Kevin E Van Cott
Journal:  Glycobiology       Date:  2008-05-02       Impact factor: 4.313

7.  Comparative rates of transfer of N-acetylneuraminic acid to acceptors bearing one or more Gal(beta 1-4)GlcNAc terminus by the Gal(beta 1-4)GlcNAc(NeuAc-Gal) (alpha 2-6)-sialyltransferase from embryonic chicken liver. Utilization of oligosaccharides as acceptors in sialyltransferase assays.

Authors:  B Bendiak; G M Cook
Journal:  Biochem J       Date:  1983-07-01       Impact factor: 3.857

8.  The complete amino acid sequence of bovine antithrombin (ATIII).

Authors:  H Mejdoub; M Le Ret; Y Boulanger; M Maman; J Choay; J Reinbolt
Journal:  J Protein Chem       Date:  1991-04

9.  Repeated batch cultivation of rBHK cells on Cytodex 3 microcarriers: antithrombin III, amino acid, and fatty acid metabolic quotients.

Authors:  G Schmid; H Zilg; R Johannsen
Journal:  Appl Microbiol Biotechnol       Date:  1992-12       Impact factor: 4.813

10.  Oligosaccharide structures mediating agglutination of sheep erythrocytes by Staphylococcus saprophyticus.

Authors:  A Gunnarsson; P A Mårdh; A Lundblad; S Svensson
Journal:  Infect Immun       Date:  1984-07       Impact factor: 3.441
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