Corticosterone catabolism by mouse liver: interactions between genotype and diet.

Corticosterone reduction was greater in liver homogenates from C57BL/10ScSn mice than in homogenates from DBA/2J mice. The reactions were stimulated to the same extent by the addition of an NADPH-generating system when the mice had been on a 4% fat diet. When the mice had been on a fat-free diet for 3 days, the generating system produced a much greater effect on homogenates from DBA mice. C57BL/Tb mice resembled C67BL/10ScSn mice with CBA/FaCam mice were similar to DBA/2J mice.