Literature DB >> 7371792

Effects of probenecid on plasma/tissue distribution of 14C-benzylpenicillin in rats.

H Bergholz, R R Erttmann, K H Damm.   

Abstract

Probenecid (50 mg . kg-1) was found to induce an increase of the plasma concentration of 14C-benzylpenicillin with a decrease of the concentration in liver and kidney. Accumulation in corresponding tissue slices was reduced by probenecid. Therefore, the well known increase of penicillin in plasma after probenecid seems to be not only due to an inhibition of renal excretion but also to a reduced tissue uptake in liver and kidney.

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Year:  1980        PMID： 7371792     DOI： 10.1007/bf01952309

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  On the mechanism of action of probenecid on renal tubular secretion.

Authors:  I M WEINER; J A WASHINGTON; G H MUDGE
Journal:  Bull Johns Hopkins Hosp       Date:  1960-06

2.  'Benemid,' p-(di-n-propylsulfamyl)-benzoic acid; its renal affinity and its elimination.

Authors:  K H BEYER; H F RUSSO; E K TILLSON; A K MILLER; W F VERWEY; S R GASS
Journal:  Am J Physiol       Date:  1951-09

3.  Functional characteristics of transport mechanisms.

Authors:  K H BEYER
Journal:  J Pharmacol Exp Ther       Date:  1950-08       Impact factor: 4.030

4.  [The effect of probenecid on the distribution of digitoxin, digoxin and ouabain in the mouse].

Authors:  K H Damm; W Braun; H Heckert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

5.  Effects of probenecid on the distribution, elimination, and passage into milk of benzylpenicillin, ampicillin and cloxacillin.

Authors:  G Ziv; F G Sulman
Journal:  Arch Int Pharmacodyn Ther       Date:  1974-02

6.  The effects of salicylate and probenecid on the cerebrospinal fluid transport of penicillin, aminosalicyclic acid and iodide.

Authors:  R Spector; A V Lorenzo
Journal:  J Pharmacol Exp Ther       Date:  1974-01       Impact factor: 4.030

7.  Modification of penicillin distribution and elimination by probenecid.

Authors:  M Gibaldi; D Davidson; M E Plaut; M A Schwartz
Journal:  Int Z Klin Pharmakol Ther Toxikol       Date:  1970-05

8.  [Effect of probenecid in penicillin therapy].

Authors:  C Simon
Journal:  Monatsschr Kinderheilkd       Date:  1973-07

9.  Treatment of syphilis and gonorrhea.

Authors: 
Journal:  Med Lett Drugs Ther       Date:  1977-12-30       Impact factor: 1.909

10.  Blood-brain and CSF barriers to penicillin and related organic acids.

Authors:  R A Fishman
Journal:  Arch Neurol       Date:  1966-08
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