Literature DB >> 7371769

Antipyrine metabolism in cancer patients.

T Higuchi, T Nakamura, H Uchino.   

Abstract

The metabolism of antipyrine was studied in cancer patients. Antipyrine elimination might be decreased in cancer patients. Increase in antipyrine half-life is not primarily due to the presence of a tumor but rather to the nutritional status and liver function of an individual.

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Year:  1980        PMID： 7371769     DOI： 10.1007/bf01953753

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  The estimation of antipyrine in biological materials.

Authors:  B B BRODIE; J AXELROD
Journal:  J Biol Chem       Date:  1949-05       Impact factor: 5.157

2.  Metabolic disposition of antipyrine in patients with lung cancer.

Authors:  C Tschanz; C E Hignite; D H Huffman; D L Azarnoff
Journal:  Cancer Res       Date:  1977-11       Impact factor: 12.701

3.  Hepatic microsomal drug metabolism after administration of endotoxin in rats.

Authors:  F Gorodischer; J Krasner; J J McDevitt; J P Nolan; S J Yaffe
Journal:  Biochem Pharmacol       Date:  1976-02-01       Impact factor: 5.858

4.  Effects of phenobarbital and endotoxin on the lethality and metabolism of 6-mercaptopurine in male BALB/c mice.

Authors:  T Higuchi; T Nakamura; H Uchino
Journal:  Cancer Res       Date:  1977-10       Impact factor: 12.701

5.  Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat.

Authors:  J L Cohen; J Y Jao
Journal:  J Pharmacol Exp Ther       Date:  1970-08       Impact factor: 4.030

6.  Letter: Increased warfarin requirement during mercaptopurine therapy: a new drug interaction.

Authors:  A S Spiers; R S Mibashan
Journal:  Lancet       Date:  1974-07-27       Impact factor: 79.321

7.  Impairement of drug metabolism in tumor-bearing animals.

Authors:  R Rosso; M G Donelli; G Franchi; S Garattini
Journal:  Eur J Cancer       Date:  1971-12       Impact factor: 9.162

8.  Decrease in the substrate interaction with cytochrome P-450 in drug hydroxylation by liver microsomes from rats bearing Walker 256 carcinosarcoma.

Authors:  R Kato; A Takanaka; A Takahashi
Journal:  Gan       Date:  1970-08

9.  Mechanism of enhanced toxicity of 6-mercaptopurine with endotoxin.

Authors:  T Higuchi; T Nakamura; H Uchino
Journal:  Biochem Pharmacol       Date:  1978       Impact factor: 5.858

10.  Determinants of serum antipyrine half-lives in patients with liver disease.

Authors:  R A Branch; C M Herbert; A E Read
Journal:  Gut       Date:  1973-07       Impact factor: 23.059
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  1 in total

1.  Effects of advanced leukemia on hepatic drug-metabolizing activity in the mouse.

Authors:  G Powis; R N Harris; P J Basseches; K S Santone
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333
  1 in total

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