| Literature DB >> 7371727 |
Abstract
The effects of low concentrations of 4-aminopyridine (4-AP) were studied on the frog sinus venosus by means of intracellular microelectrodes. 4-AP depressed spontaneous automaticity. This effect was not reversed by atropine. 4-AP also prolonged the sinus action potential repolarization and slowed the rate of diastolic depolarization. These effects are attributed to blockade of potassium conductance.Entities:
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Year: 1980 PMID： 7371727 DOI： 10.1016/0014-2999(80)90101-6
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432