Decreasing sample volume used in the "Sequential Multichannel Analyzer Computerized" (SMAC).

We describe modifications to two cartridges, those for alkaline phosphatase and creatinine, on an 18-channel SMAC (Sequential Multichannel Analyzer Computerized), which allow all 18 tests to be run with a commonly prediluted sample. This decreases the required sample size and eliminates the problem of fibrin clots in the stream-splitter on the main sample line. The modifications can be made rapidly and require few new components. Accuracy, precision, linearity, and carryover are acceptable after these modifications, as judged by comparison with premodification data. Some financial savings ensue from the decreased consumption of reagents and the fewer repeat analyses necessitated by clotting problems.