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Literature DB >> 7370167

Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro.

Abstract

Chinese hamster, HeLa and HAK cells were treated with methotrexate (MTX) to determine the dependence of its effect on drug concentration and exposure time. With a broad range of survival curves for Chinese hamster cells, cell survival is an exponential function of exposure time and a power function of drug concentration. The data allow a mathematical description to be made of the interdependence of MTX concentration and drug exposure in relation to cell survival.

Entities: CellLine Chemical Species

Mesh：

Substances：
Methotrexate

Year: 1980 PMID： 7370167 PMCID： PMC2010205 DOI： 10.1038/bjc.1980.40

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

15 in total

1. Progress report on high-dose methotrexate (NSC-740) with citrovorum rescue in the treatment of metastatic bone tumors.

Authors: N Jaffe
Journal: Cancer Chemother Rep Date: 1974 Mar-Apr

2. Active transport of aminopterin in Yoshida sarcoma cells.

Authors: A Y Divekar; N R Vaidya; B M Braganca
Journal: Biochim Biophys Acta Date: 1967

3. Phase I study of high doses of methotrexate with citrovorum factor in patients with lung cancer.

Authors: I Djerassi; C J Rominger; J S Kim; J Turchi; U Suvansri; D Hughes
Journal: Cancer Date: 1972-07 Impact factor: 6.860

4. Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.

Authors: I D Goldman; N S Lichtenstein; V T Oliverio
Journal: J Biol Chem Date: 1968-10-10 Impact factor: 5.157

5. On the nature of permeability of sarcoma-180 cells to amethopterin in vitro.

Authors: M T Hakala
Journal: Biochim Biophys Acta Date: 1965-05-25

6. Some observations on the combined effects of x-rays and methotrexate on human tumor cells in vitro with possible relevance to their most useful combination in radiotherapy.

Authors: R J Berry
Journal: Am J Roentgenol Radium Ther Nucl Med Date: 1968-03

7. Cell killing studies on the mode of action of methotrexate on L-cells in vitro.

Authors: J Borsa; G F Whitmore
Journal: Cancer Res Date: 1969-04 Impact factor: 12.701

8. Comparison of the dose- and timesurvival curves for normal hematopoietic and lymphoma colony-forming cells exposed to vinblastine, vincristine, arabinosylcytosine, and amethopterin.

Authors: W R Bruce; B E Meeker; W E Powers; F A Valeriote
Journal: J Natl Cancer Inst Date: 1969-06 Impact factor: 13.506

9. An effective low-dose intermittent cyclophosphamide, methotrexate, and 5-fluorouracil treatment regimen for metastatic breast cancer.

Authors: R H Creech; R B Catalano; M J Mastrangelo; P F Engstrom
Journal: Cancer Date: 1975-04 Impact factor: 6.860

10. Hydroxyurea: differential lethal effects on cultured mammalian cells during the cell cycle.

Authors: W K Sinclair
Journal: Science Date: 1965-12-24 Impact factor: 47.728

6 in total

1. A slow-release methotrexate formulation for intrathecal chemotherapy.

Authors: E Chatelut; T Kim; S Kim
Journal: Cancer Chemother Pharmacol Date: 1993 Impact factor: 3.333

2. Comparison of serum and cerebrospinal fluid levels of methotrexate in man during high-dose chemotherapy for aggressive non-Hodgkin's lymphoma.

Authors: N L Gilchrist; J Caldwell; I D Watson; D Cunningham; G J Forrest; M Soukop; M Stewart; W Fitch
Journal: Cancer Chemother Pharmacol Date: 1985 Impact factor: 3.333

3. Long-duration intracavitary infusion of methotrexate with systemic leucovorin protection in patients with malignant effusions.

Authors: S B Howell; B B Chu; W E Wung; B M Metha; J Mendelsohn
Journal: J Clin Invest Date: 1981-04 Impact factor: 14.808