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Literature DB >> 7369870

Fatal sotalol poisoning.

Abstract

Sotalol [4-(2-isopropylamino-1-hydroxyethyl)-methane-sulfonanilide hydrochloride] is a beta-adrenergic blocking agent. Despite the widespread use of these drugs, poisonings are not frequent. In this report the authors describe the first recorded case of fatal sotalol overdosage to their knowledge. The results of toxicological analysis, performed by a specially developed method, are presented, and compared with findings in fatal intoxications with other beta-adrenergic blocking agents.

Entities: Chemical Disease

Mesh：

Substances：
Sotalol

Year: 1980 PMID： 7369870 DOI： 10.1007/bf00297587

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

9 in total

1. Letter: Massive intoxication with metoprolol.

Authors: B H Moller
Journal: Br Med J Date: 1976-01-24

2. Human pharmacokinetics of sotalol.

Authors: M Anttila; M Arstila; M Pfeffer; R Tikkanen; V Vallinkoski; H Sundquist
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1976-07

3. Attempted suicide with 5.1 g of propranolol. A case report.

Authors: J Lagerfelt; G Matell
Journal: Acta Med Scand Date: 1976

4. Antihypertensive effects of practolol and sotalol.

Authors: H Sundquist; M Anttila; M Arstila
Journal: Clin Pharmacol Ther Date: 1974-09 Impact factor: 6.875

5. Separation and spectrofluorometric assay of the -adrenergic blocker sotalol from blood and urine.

Authors: E R Garrett; K Schnelle
Journal: J Pharm Sci Date: 1971-06 Impact factor: 3.534

6. Suicide attempt with practolol.

Authors: P Karhunen; G Härtel
Journal: Br Med J Date: 1973-04-21

7. GLC determination of propranolol, other beta-blocking drugs, and metabolites in biological fluids and tissues.

Authors: T Walle
Journal: J Pharm Sci Date: 1974-12 Impact factor: 3.534

8. A death involving propranolol (Inderal).

Authors: R Gault; J R Monforte; S Khasnabis
Journal: Clin Toxicol Date: 1977 Impact factor: 4.467

9. The effect of end-stage renal failure and haemodialysis on the elimination kinetics of sotalol.

Authors: T B Tjandramaga; R Verbeeck; J Thomas; R Verbesselt; R Verberckmoes; P J Schepper
Journal: Br J Clin Pharmacol Date: 1976-04 Impact factor: 4.335

9 in total

8 in total

Fatal sotalol poisoning.

1. Letter: Massive intoxication with metoprolol.

2. Human pharmacokinetics of sotalol.

3. Attempted suicide with 5.1 g of propranolol. A case report.

4. Antihypertensive effects of practolol and sotalol.

5. Separation and spectrofluorometric assay of the -adrenergic blocker sotalol from blood and urine.

6. Suicide attempt with practolol.

7. GLC determination of propranolol, other beta-blocking drugs, and metabolites in biological fluids and tissues.

8. A death involving propranolol (Inderal).

9. The effect of end-stage renal failure and haemodialysis on the elimination kinetics of sotalol.

1. [Torsade de pointes tachycardia during administration of quinidine and verapamil in atrial fibrillation].

2. Prolonged Q-T interval and severe tachyarrhythmias, common features of sotalol intoxication.

Review 3. Sotalol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use.

Review 4. Sotalol. An updated review of its pharmacological properties and therapeutic use in cardiac arrhythmias.

Review 5. Class III antiarrhythmics in overdose. Presenting features and management principles.

Review 6. QT-interval prolonging drugs: mechanisms and clinical relevance of their arrhythmogenic hazards.

Review 7. Drug-induced torsade de pointes. Incidence, management and prevention.

8. Sotalol poisoning associated with asystole.