| Literature DB >> 7369288 |
H P Van Geijn, W M Kaylor, K R Nicola, F P Zuspan.
Abstract
A noninvasive technique in an animal model that consistently produces severe intrauterine growth retardation in the Sprague-Dawley rat is described. Maternal rats were exposed continuously to a hypoxic environment (9.5% oxygen) between days 10 and 22 of gestation. This oxygen concentration was marginal for the survival of the Sprague-Dawley rat fetus. The results demonstrate decreases of 61% in litter size, 36% in fetal body weight, and 23% in fetal brain weight. The effect of hypoxia was differentiated from that of a reduced voluntary food intake by the maternal rats occurring simultaneously during the period of hypoxic exposure.Entities:
Mesh：
Year: 1980 PMID： 7369288 DOI： 10.1016/0002-9378(80)90384-1
Source DB: PubMed Journal: Am J Obstet Gynecol ISSN： 0002-9378 Impact factor: 8.661