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Literature DB >> 736794

Comparison of the therapeutic effects of five antiviral agents on cutaneous herpesvirus infection in guinea pigs.

Abstract

Cutaneous herpesvirus infection of guinea pigs has been evaluated as a model for testing antiviral compounds. Six infected sites on each animal can be used independently for local treatment. The severity of the infection has been graded in a score system. The cumulative scores during infection and the time to healing can be used to determine antiviral effects. The effects of adenine arabinoside, cytosine arabinoside, iododeoxyuridine, ribavirin and phosphonoacetic acid on the cutaneous infection was compared. Phosphonoacetic acid was the only compound with a good therapeutic activity against herpesvirus infection, causing a reduction of both the cumulative score and the time to healing. Phosphonoacetic acid was skin irritating at 2 per cent, but at 1 per cent, which still had a good therapeutic activity, skin irritation was seen only occasionally.

Entities: Chemical Disease Species

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Year: 1978 PMID： 736794 DOI： 10.1007/bf01317820

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

12 in total

1. Herpes simplex keratitis: animal models to guide the selection and optimal delivery of antiviral chemotherapy.

Authors: M G Falcon; B R Jones
Journal: J Antimicrob Chemother Date: 1977-03 Impact factor: 5.790

2. Inhibition of herpesvirus DNA synthesis by 9-beta-D-arabinofuranosyladenine in cellular and cell-free systems.

Authors: W E Müller; R K Zahn; K Bittlingmaier; D Falke
Journal: Ann N Y Acad Sci Date: 1977-03-04 Impact factor: 5.691

3. Guinea pig model for cutaneous herpes simplex virus infection.

Authors: W R Hubler; T D Felber; D Troll; M Jarratt
Journal: J Invest Dermatol Date: 1974-02 Impact factor: 8.551

4. Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells.

Authors: P M Ejercito; E D Kieff; B Roizman
Journal: J Gen Virol Date: 1968-05 Impact factor: 3.891

5. Kethoxal for treatment of cutaneous herpes simplex.

Authors: G E Underwood
Journal: Proc Soc Exp Biol Med Date: 1968-10

6. Comparison of activity of herpes virus inhibitors.

Authors: P Collins; D J Bauer
Journal: J Antimicrob Chemother Date: 1977-03 Impact factor: 5.790

7. Cutaneous herpes simplex virus infection of guinea pigs as a model for antiviral chemotherapy.

Authors: T W Schafer; M Lieberman; J Everitt; P Came
Journal: Ann N Y Acad Sci Date: 1977-03-04 Impact factor: 5.691

8. The natural history of recurrent herpes simplex labialis: implications for antiviral therapy.

Authors: S L Spruance; J C Overall; E R Kern; G G Krueger; V Pliam; W Miller
Journal: N Engl J Med Date: 1977-07-14 Impact factor: 91.245

9. Suppression of herpes simplex virus infection by phosphonoacetic acid.

Authors: N L Shipkowitz; R R Bower; R N Appell; C W Nordeen; L R Overby; W R Roderick; J B Schleicher; A M Von Esch
Journal: Appl Microbiol Date: 1973-09

Review 10. Treatment of infections due to Herpesvirus in humans: a critical review of the state of the art.

Authors: C A Alford; R J Whitley
Journal: J Infect Dis Date: 1976-06 Impact factor: 5.226

13 in total

1. Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl) guanine (BRL 39123) in animals.

Authors: M R Boyd; T H Bacon; D Sutton
Journal: Antimicrob Agents Chemother Date: 1988-03 Impact factor: 5.191

2. Topical delivery of liposomally encapsulated interferon evaluated in a cutaneous herpes guinea pig model.

Authors: N Weiner; N Williams; G Birch; C Ramachandran; C Shipman; G Flynn
Journal: Antimicrob Agents Chemother Date: 1989-08 Impact factor: 5.191

3. Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.

Authors: E de Clercq
Journal: Antimicrob Agents Chemother Date: 1984-08 Impact factor: 5.191

4. Mode of action, toxicity, pharmacokinetics, and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir.

Authors: A Larsson; K Stenberg; A C Ericson; U Haglund; W A Yisak; N G Johansson; B Oberg; R Datema
Journal: Antimicrob Agents Chemother Date: 1986-10 Impact factor: 5.191

5. Penetration of guinea pig skin by acyclovir in different vehicles and correlation with the efficacy of topical therapy of experimental cutaneous herpes simplex virus infection.

Authors: S L Spruance; M B McKeough; J R Cardinal
Journal: Antimicrob Agents Chemother Date: 1984-01 Impact factor: 5.191

6. Inhibition of herpesvirus multiplication in guinea pig skin by antiviral compounds.

Authors: S Alenius
Journal: Arch Virol Date: 1980 Impact factor: 2.574

7. Cutaneous herpes simplex virus infection of the guinea pig: lack of resistance to acyclovir and phosphonoformic acid after topical treatment.

Authors: A Poryo; R Wigand
Journal: Med Microbiol Immunol Date: 1984 Impact factor: 3.402

8. Ineffectiveness of adenine arabinoside and adenine arabinoside 5'-monophosphate in simian varicella infection.

Authors: K F Soike; A D Felsenfeld; S Gibson; P J Gerone
Journal: Antimicrob Agents Chemother Date: 1980-07 Impact factor: 5.191

9. Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.

Authors: J Descamps; E De Clercq; P J Barr; A S Jones; R T Walker; P F Torrence; D Shugar
Journal: Antimicrob Agents Chemother Date: 1979-11 Impact factor: 5.191

10. Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine.

Authors: A C Ericson; A Larsson; F Y Aoki; W A Yisak; N G Johansson; B Oberg; R Datema
Journal: Antimicrob Agents Chemother Date: 1985-05 Impact factor: 5.191