Literature DB >> 7367883

Calcification inside artificial hearts: inhibition by warfarin-sodium.

W S Pierce, J H Donachy, G Rosenberg, R E Baier.   

Abstract

Intracavitary calcium phosphate deposits were observed in smooth, elastomeric blood pump sacs implanted in male calves for periods of 115 to 166 days. These deposits occurred predominantly on the flexing surface of the sacs. In contrast, similar pump sacs remained generally free of mineral deposits for up to 150 days in calves treated with the anticoagulant warfarin-sodium. These results implicate a vitamin K-dependent process in calcium phosphate deposition on elastomeric sacs.

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Year:  1980        PMID: 7367883     DOI: 10.1126/science.7367883

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  3 in total

Review 1.  Post-translational carboxylation of preprothrombin.

Authors:  B C Johnson
Journal:  Mol Cell Biochem       Date:  1981-08-11       Impact factor: 3.396

2.  Biologic determinants of dystrophic calcification and osteocalcin deposition in glutaraldehyde-preserved porcine aortic valve leaflets implanted subcutaneously in rats.

Authors:  R J Levy; F J Schoen; J T Levy; A C Nelson; S L Howard; L J Oshry
Journal:  Am J Pathol       Date:  1983-11       Impact factor: 4.307

3.  Calcification in chronically-implanted blood pumps: experimental results and review of the literature.

Authors:  S A Turner; M I Bossart; J D Milam; J M Fuqua; S R Igo; M G McGee; O H Frazier
Journal:  Tex Heart Inst J       Date:  1982-06
  3 in total

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