Literature DB >> 7367453

Nicotine and amphetamine: differential tolerance and no cross-tolerance for ingestive effects.

K Baettig, J R Martin, W Classen.   

Abstract

Rats chronically treated twice daily with nicotine (0.4 mg/kg, SC) or d,1-amphetamine (1.5 mg/kg, SC) exhibited different patterns of anorexia, hypodipsia, and body weight loss. Amphetamine-treated rats developed tolerance to these ingestive effects and to weight loss, whereas nicotine-injected rats did not. There was little, if any, evidence for cross-tolerance when the drugs were switched between the two groups. These results indicate that different mechanisms underlie the ingestive effects of nicotine and amphetamine.

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Year:  1980        PMID： 7367453     DOI： 10.1016/0091-3057(80)90423-2

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  7 in total

1.  Nicotine analog inhibition of nicotine self-administration in rats.

Authors:  Neil E Rowland; Kimberly Robertson; Ferenc Soti; William R Kem
Journal:  Psychopharmacology (Berl)       Date:  2008-06-07       Impact factor: 4.530

2.  Super-reactivity to amphetamine toxicity induced by schedule of reinforcement.

Authors:  M Valencia-Flores; D N Velázquez-Martínez; J E Villarreal
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

3.  Characterization of nicotine's ability to serve as a negative feature in a Pavlovian appetitive conditioning task in rats.

Authors:  Rick A Bevins; Jamie L Wilkinson; Matthew I Palmatier; Hannah L Siebert; Steven M Wiltgen
Journal:  Psychopharmacology (Berl)       Date:  2005-07-27       Impact factor: 4.530

4.  Different effects of chronic nicotine treatment regimens on body weight and tolerance in the rat.

Authors:  M M Morgan; G Ellison
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

5.  Positive allosteric modulation of α4β2 nicotinic acetylcholine receptors as a new approach to smoking reduction: evidence from a rat model of nicotine self-administration.

Authors:  Xiu Liu
Journal:  Psychopharmacology (Berl)       Date:  2013-05-28       Impact factor: 4.530

6.  Some effects of nicotine on food and water intake in undeprived rats.

Authors:  P B Clarke; R Kumar
Journal:  Br J Pharmacol       Date:  1984-05       Impact factor: 8.739

7.  The effects of long-term nicotine treatment on locomotion, exploration and memory in young and old rats.

Authors:  H Welzl; B Alessandri; R Oettinger; K Bätig
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530
  7 in total

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